Frontiers in Physiology, 2020 Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether derived from the diet or from fermentation in the colon, has been implicated in a range of health benefits.
John R. Moffett +4 more
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Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro [PDF]
, 2016 Oligodendroglial cells are known to de-acetylate the N-acetylaspartate (NAA) synthesized and released by neurons and use it for lipid synthesis. However, the role of NAA regarding their intermediary metabolism remains poorly understood.
AC Yu +49 more
core +5 more sources
Combined transcriptome and proteome analyses reveal differences in the longissimus dorsi muscle between Kazakh cattle and Xinjiang brown cattle [PDF]
Animal Bioscience, 2021 Objective With the rapid development of proteomics sequencing and RNA sequencing technology, multi-omics analysis has become a current research hotspot.
XiangMin Yan +9 more
doaj +1 more source
Combining Double Fluorescence In Situ Hybridization with Immunolabelling for Detection of the Expression of Three Genes in Mouse Brain Sections [PDF]
, 2016 Detection of gene expression in different types of brain cells e.g., neurons, astrocytes, oligodendrocytes, oligodendrocyte precursors and microglia, can be hampered by the lack of specific primary or secondary antibodies for immunostaining.
Fudge, A +4 more
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Mutational analysis of aspartoacylase: Implications for Canavan Disease [PDF]
Brain Research, 2007 Mutations that result in near undetectable activity of aspartoacylase, which catalyzes the deacetylation of N-acetyl-l-aspartate, correlate with Canavan Disease, a neurodegenerative disorder usually fatal during childhood. The underlying biochemical mechanisms of how these mutations ablate activity are poorly understood.
Jeremy R, Hershfield +3 more
openaire +2 more sources
Canavan Disease: Clinical and laboratory profile from Southern part of India
Annals of Indian Academy of Neurology, 2021 Background: Canavan disease (CD) is an autosomal recessively inherited leukodystrophy. It affects one in 6,400 to 13,500 people in the Jewish population.
Vykuntaraju K Gowda +4 more
doaj +1 more source
Stable isotope dilution analysis of N-acetylaspartic acid in CSF, blood, urine and amniotic fluid: Accurate postnatal diagnosis and the potential for prenatal diagnosis of canavan disease [PDF]
, 1991 A sensitive and selective analytical technique is described for the determination of N-acetylaspartic acid in body fluids using stable isotope dilution in combination with positive chemical ionization mass spectrometry with selected ion monitoring ...
Brink, H.J. (H.) ten +8 more
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Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development [PDF]
, 2017 We have identified SHATI/NAT8L in the brain of mice treated with methamphetamine. Recently, it has been reported that SHATI is N-acetyltransferase 8-like protein (NAT8L) that produces N-acetylaspatate (NAA) from aspartate and acetyl-CoA.
Furukawa-Hibi Yoko +8 more
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Frontiers in Molecular Neuroscience, 2017 Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the present
Abhilash P. Appu +7 more
doaj +1 more source
iScience, 2022 Summary: Canavan disease (CD) is a devastating neurological disease that lacks effective therapy. Because CD is caused by mutations of the aspartoacylase (ASPA) gene, we introduced the wild-type (WT) ASPA gene into patient iPSCs through lentiviral ...
Jianfei Chao +12 more
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