Results 1 to 10 of about 25,205 (77)

Odontogenic Sinusitis Causing Invasive <i>Aspergillosis niger</i> Infection With Para-Meningeal Abscess. [PDF]

Clin Case Rep
ABSTRACT Invasive aspergillosis is considered to occur in patients with neutropenia and cellular immunodeficiency, but co‐infection with bacterial infections due to odontogenic infections is rare but possible. Diagnosis relies on culture and tissue examination as sensitivity to serum galactomannan antigen is low due to immunocompetence.
Ishikawa K, Mori N.
europepmc   +2 more sources

Efficacy of Low-Dose Fluconazole for Primary Prophylaxis of Invasive Candida Infections in Patients With Acute Leukemia: A Double-Blind Randomized Clinical Trial. [PDF]

Cancer Med
ABSTRACT Background Invasive fungal infections (IFIs), particularly Candida infections, are a significant cause of morbidity and mortality in patients with acute leukemia. While fluconazole is widely used for prophylaxis, the optimal dosing regimen remains uncertain.
Savary-Kouzehkonan R, Sadeghi K, Rad S, Alijani N, Baseri Z, Vaezi M, Mousavi SA, Shahrami B.   +7 more
europepmc   +2 more sources

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

Secondary infections worsen the outcome of COVID‐19 in patients with hematological malignancies: A report from the ITA‐HEMA‐COV

Hematological Oncology, Volume 40, Issue 5, Page 846-856, December 2022., 2022
Abstract The impact of secondary infections (SI) on COVID‐19 outcome in patients with hematological malignancies (HM) is scarcely documented. To evaluate incidence, clinical characteristics, and outcome of SI, we analyzed the microbiologically documented SI in a large multicenter cohort of adult HM patients with COVID‐19.
Patrizia Zappasodi, Chiara Cattaneo, Virginia Valeria Ferretti, Roberto Mina, Andrés José María Ferreri, Francesco Merli, Margherita Oberti, Mauro Krampera, Alessandra Romano, Caterina Zerbi, Jacqueline Ferrari, Michele Cavo, Marco Salvini, Lorenza Bertù, Nicola Stefano Fracchiolla, Francesco Marchesi, Massimo Massaia, Vincenzo Marasco, Roberto Cairoli, Anna Maria Scattolin, Alessandro Maria Vannucchi, Carlo Gambacorti‐Passerini, Pellegrino Musto, Filippo Gherlinzoni, Antonio Cuneo, Antonello Pinto, Livio Trentin, Monica Bocchia, Sara Galimberti, Elisa Coviello, Maria Chiara Tisi, Alessandro Morotti, Brunangelo Falini, Mauro Turrini, Agostino Tafuri, Atto Billio, Massimo Gentile, Roberto Massimo Lemoli, Adriano Venditti, Matteo Giovanni Della Porta, Francesco Lanza, Luigi Rigacci, Patrizia Tosi, Sara Mohamed, Alessandro Corso, Mario Luppi, Nicola Giuliani, Alessandro Busca, Livio Pagano, Raffaele Bruno, Paolo Antonio Grossi, Paolo Corradini, Francesco Passamonti, Luca Arcaini, on behalf of the ITA‐HEMA‐COV Investigators   +54 more
wiley   +1 more source

Pharmacokinetics, safety of a single dose and multiple doses of voriconazole injection of two formulations, in Chinese healthy volunteers

Precision Medical Sciences, Volume 11, Issue 4, Page 186-194, December 2022., 2022
Voriconazole injection of Hailing Pharmaceutical Group has achieved a breakthrough in improving the solubility of voriconazole with different excipients for the first time in China. We evaluated the pharmacokinetics (PK) and safety of single/multiple doses of voriconazole injection of Hailing Pharmaceutical Group (Test, T), a biosimilar to Vfend ...
Chunqi Huang, Yannan Wang, Yi Wu, Sisi Lin, Rui Hao, Jin Yu, Lu Fang, Jingjing Zhu, Di Zhao, Shengjia Tong, Yongkai Si, Tiantian Ye, Zeyu Wu, Hui Huang, Zhuoyan Wang, Ying Wang   +15 more
wiley   +1 more source

Chinese expert consensus on the multidisciplinary management of pneumonitis associated with immune checkpoint inhibitor

Thoracic Cancer, Volume 13, Issue 23, Page 3420-3430, December 2022., 2022
Chinese expert consensus on the multidisciplinary management of pneumonitis associated with immune checkpoint inhibitor. Abstract Immune checkpoint inhibitors (ICIs) have successfully treated a number of different types of cancer, which is of great significance for cancer treatment.
Wenxian Wang, Qian Wang, Chunwei Xu, Ziming Li, Zhengbo Song, Yongchang Zhang, Xiuyu Cai, Shirong Zhang, Bin Lian, Wen Li, Anwen Liu, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Xingxiang Pu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Congying Xie, Junping Zhang, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Liping Wang, Youcai Zhu, Xiao Hu, Yanru Xie, Xinqing Lin, Jing Cai, Fen Lan, Huijing Feng, Lin Wang, Wang Yao, Xuefei Shi, Jianhui Huang, Huafei Chen, Yinbin Zhang, Pingli Sun, Bing Wan, Fei Pang, Zanmei Xu, Kai Wang, Yuanli Xia, Mingxiang Ye, Dong Wang, Qing Wei, Shuitu Feng, Jianya Zhou, Jiexia Zhang, Donglai Lv, Wenbin Gao, Jing Kang, Genhua Yu, Xianbin Liang, Chengtao Yu, Lin Shi, Nong Yang, Lin Wu, Zhuan Hong, Wei Hong, Meiyu Fang, Yiping Zhang, Yuanzhi Lu, Guansong Wang, Shenglin Ma, Lu Si, Wenfeng Fang, Yong Song   +79 more
wiley   +1 more source

Design and conduct considerations for studies in patients with hepatic impairment

Clinical and Translational Science, Volume 16, Issue 1, Page 50-61, January 2023., 2023
Abstract Despite the liver being the primary site for clearance of xenobiotics utilizing a myriad of mechanisms ranging from cytochrome P450 enzyme pathways, glucuronidation, and biliary excretion, there is a dearth of information available as to how the severity of hepatic impairment (HI) can alter drug absorption and disposition (i.e ...
Paulien Ravenstijn, Manoranjenni Chetty, Pooja Manchandani, Mohamed Elmeliegy, Hisham Qosa, Islam Younis   +5 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Differentiating reactive and neoplastic gamma‐delta (γδ) T‐cell expansions in the peripheral blood and bone marrow

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract The clinical and immunophenotypic attributes of reactive γδ T‐cell expansions are less well characterized than their malignant counterparts, which can pose diagnostic challenges. This study aims to investigate the characteristics and long‐term clinical outcomes of reactive γδ T‐cell expansions.
Hamza Tariq, Zubair Ilyas, Lucy Fu, Yijie Liu, Qing Ching Chen, Kristy Wolniak, Yi‐Hua Chen   +6 more
wiley   +1 more source

An investigation into the transcription factors and regulatory mechanisms of Aspergillus

Food Safety and Health, EarlyView.
Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley   +1 more source