Results 41 to 50 of about 45,456 (232)

Immunotherapy of aspergillosis [PDF]

Clinical Microbiology and Infection, 2012
Management of invasive aspergillosis in high-risk patients remains challenging. There is an increasing demand for novel therapeutic strategies aimed at enhancing or restoring antifungal immunity in immunocompromised patients. In this regard, modulation of specific innate immune functions and vaccination are promising immunotherapeutic strategies ...
Carvalho A., Cunha C., BISTONI, Francesco, ROMANI, Luigina   +3 more
openaire   +4 more sources

In Vitro Pharmacokinetic/Pharmacodynamic Modeling of Voriconazole Activity against Aspergillus Species in a New In Vitro Dynamic Model [PDF]

, 2012
The pharmacodynamics (PD) of voriconazole activity against Aspergillus spp. were studied using a new in vitro dynamic model simulating voriconazole human pharmacokinetics (PK), and the PK-PD data were bridged with human drug exposure to assess the ...
Zerva, Loukia, Meletiadis, Joseph, Velegraki, Aristea, Elefanti, Antigoni, Al Saigh, Rafal   +4 more
core   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Epidemiology of Aspergillosis in Cancer Patients in Taiwan

Infection and Drug Resistance, 2022
Chien-An Chen,1,2,* Chung-Han Ho,3– 5,* Yu-Cih Wu,3 Yi-Chen Chen,3 Jhi-Joung Wang,3 Kuang-Ming Liao6 1Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, 71004, Taiwan; 2Division of Hospital ...
Chen CA, Ho CH, Wu YC, Chen YC, Wang JJ, Liao KM   +5 more
doaj  

Invasive fungal infection by Aspergillus flavus in immunocompetent hosts: A case series and literature review

Medical Mycology Case Reports, 2019
Invasive aspergillosis usually affects immunocompromised hosts with variable manifestations depending on the site of infection. In this article, we present two cases of invasive Aspergillosis in two non-immunocompromised patients; both cases had a ...
Ana María Garcia-Giraldo, Barbara Lucia Mora, Jorge Mario Loaiza-Castaño, Jorge Andrés Cedano, Fernando Rosso   +4 more
doaj   +1 more source

Delayed Diagnosis of a Diffuse Invasive Gastrointestinal Aspergillosis in an Immunocompetent Patient [PDF]

, 2020
Invasive aspergillosis represents a clinical picture frequently associated with host’s immunosuppression which usually involves a high morbidity and mortality.
Mühlethaler, K., Springe, D., K. Mühlethaler, Guglielmetti, S, L. Ebnöther, D. Springe, Bigler, A., Delgado, M, Ebnöther, L., C. M. Jaccard, S. Guglielmetti, A. Bigler, M. Delgado, Jaccard, C. M.   +13 more
core   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, EarlyView.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

Treatment Of Invasive Aspergillosis [PDF]

, 2018
Invasive aspergillosis (IA) is an infectious disease caused by Aspergillus species, is usually seen in patients with immune deficiency and has been associated with high mortality rate.
Mustafa DOĞAN, Şenay ELBASAN OMAR, Enes ARDİÇ, Rıdvan KARAALİ, İlknur ERDEM   +4 more
core  

A MIQE-Compliant Real-Time PCR Assay for Aspergillus Detection [PDF]

, 2012
PMCID: PMC3393739This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Bustin, SA, Johnson Gemma L., Bustin Stephen A., David F Bibby, Stephenie Wong, Wong, S, Agrawal Samir G., Agrawal, SG, Gemma L Johnson, Bibby, DF, Stephen A Bustin, Bibby David F., Samir G Agrawal, Johnson, GL, Wong Stephenie   +14 more
core   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source