Results 51 to 60 of about 45,302 (241)

Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation

open access: yesЖурнал инфектологии, 2018
The aim: to assess the incidence of various forms of pulmonary aspergillosis in patients with cystic fibrosis.Materials and methods. In 2014-2017 yy. in prospective study in  different regions of Russia were included 190 patients with cystic  fibrosis ...
Ya. I. Kozlova   +11 more
doaj   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp   +6 more
wiley   +1 more source

Treatment Of Invasive Aspergillosis [PDF]

open access: yes, 2018
Invasive aspergillosis (IA) is an infectious disease caused by Aspergillus species, is usually seen in patients with immune deficiency and has been associated with high mortality rate.
Mustafa DOĞAN   +4 more
core  

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

open access: yesChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Invasive aspergillosis in an immunocompetent patient with fever and a cardiac mass

open access: yesInfectious Disease Reports, 2011
Invasive aspergillosis is an often fatal disease that usually occurs in immunocompromised patients. We report a case of invasive aspergillosis presenting as a febrile respiratory infection with a cardiac mass in an immunocompetent patient.
Matthew LaBarbera, Lester B. Jacobson
doaj   +1 more source

Immunotherapy of aspergillosis [PDF]

open access: yesClinical Microbiology and Infection, 2012
Management of invasive aspergillosis in high-risk patients remains challenging. There is an increasing demand for novel therapeutic strategies aimed at enhancing or restoring antifungal immunity in immunocompromised patients. In this regard, modulation of specific innate immune functions and vaccination are promising immunotherapeutic strategies ...
Carvalho A.   +3 more
openaire   +4 more sources

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

open access: yesAllergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama   +16 more
wiley   +1 more source

A model of cerebral aspergillosis in non-immunosuppressed nursing rats [PDF]

open access: yes, 2007
Central nervous system aspergillosis is an often fatal complication of invasive Aspergillus infection. Relevant disease models are needed to study the pathophysiology of cerebral aspergillosis and to develop novel therapeutic approaches.
Stefan Zimmerli   +5 more
core   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

open access: yesAllergy, EarlyView.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton   +19 more
wiley   +1 more source

CLINICAL OBSERVATION OF CHRONIC ASPERGILLOSIS IN A PATIENT WITH SPINAL BLOOD CIRCULATION DISORDER

open access: yesМедицина в Кузбассе, 2020
Subject of research. Study of the influence of pathogenic factors and predisposing conditions on the development of aspergillosis of the central nervous system. Purpose of research – demonstration of a clinical case of chronic aspergillosis in a patient
Марина Анатольевна Пеганова   +4 more
doaj  

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