Results 11 to 20 of about 25,205 (77)

CT‐P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double‐Blind, Randomized, Active‐Controlled, Phase 3 Study

Allergy, EarlyView.
This study investigated the therapeutic equivalence of CT‐P39 (an omalizumab biosimilar) and EU‐approved reference omalizumab (ref‐OMA) in patients with chronic spontaneous urticaria. Therapeutic equivalence between CT‐P39 and ref‑OMA (300 mg) was demonstrated by the primary endpoint – confidence intervals of the treatment difference in mean change ...
Sarbjit S. Saini, Marcus Maurer, Yevgeniya Dytyatkovska, Ewa Springer, Maria Ratkova, Borislava Krusheva, Chun Wook Park, Grazyna Pulka, Marta Chełmińska, Adam Reich, Sunghyun Kim, Keumyoung Ahn, Suyoung Kim, Sewon Lee, Jieun Ka, Jongho Kim, Clive Grattan   +16 more
wiley   +1 more source

Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and Belgium

British Journal of Haematology, EarlyView.
The overall survival of patients receiving an allogeneic haematopoietic stem cell transplant (HSCT) for GATA2 deficiency was significantly better if they were transplanted recently, with a bone marrow or cord blood graft and if the transplant was performed before the onset of excess blast. Excess blast before HSCT was the only factor associated with an
Flore Sicre de Fontbrune, Florian Chevillon, Mony Fahd, Kristell Desseaux, Xavier Poiré, Edouard Forcade, Arthur Sterin, Bénédicte Neven, Virginie Gandemer, Sylvain Thepot, Alice Garnier, Bruno Lioure, Ambroise Marcais, Stephanie Nguyen‐Quoc, Suzanne Tavitian, Laure Vincent, Jean Donadieu, Matthieu Resche Riggon, Sylvie Chevret, Marlene Pasquet, Regis Peffault de Latour   +20 more
wiley   +1 more source

Myeloid neoplasm inspired intensive therapy in VEXAS syndrome: A single‐centre experience

British Journal of Haematology, EarlyView.
Summary There is still no standard of care and unmet medical needs in refractory/advanced VEXAS (vacuoles in myeloid progenitors, E1 ubiquitin activating enzyme, X‐linked, autoinflammatory manifestations and somatic) syndrome with or without associated haematological neoplasm.
Maël Heiblig, Adriana Plesa, Juliet Tantot, Yvan Jamilloux, Hélène Labussière‐Wallet, Pierre Sujobert   +5 more
wiley   +1 more source

Early Origins of Asthma and Allergies: Clues From Studies in China

Clinical &Experimental Allergy, EarlyView.
The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang, Jing Yang, Xueling Lai, Agnes Sze‐Yin Leung, Yuhan Xing, Gary Wing‐Kin Wong   +5 more
wiley   +1 more source

SAPSAM - Sparsely Annotated Pathological Sign Activation Maps - A novel approach to train Convolutional Neural Networks on lung CT scans using binary labels only [PDF]

https://biomedicalimaging.org/2019/, 2019
Chronic Pulmonary Aspergillosis (CPA) is a complex lung disease caused by infection with Aspergillus. Computed tomography (CT) images are frequently requested in patients with suspected and established disease, but the radiological signs on CT are difficult to quantify making accurate follow-up challenging.
arxiv  

AI-Driven Solutions for Falcon Disease Classification: Concatenated ConvNeXt cum EfficientNet AI Model Approach [PDF]

Falconry, an ancient practice of training and hunting with falcons, emphasizes the need for vigilant health monitoring to ensure the well-being of these highly valued birds, especially during hunting activities. This research paper introduces a cutting-edge approach, which leverages the power of Concatenated ConvNeXt and EfficientNet AI models for ...
arxiv   +1 more source

Selective changes in vasopressin neurons and astrocytes in the suprachiasmatic nucleus of Prader–Willi syndrome subjects

Journal of Neuroendocrinology, EarlyView.
Abstract The hypothalamic suprachiasmatic nucleus (SCN) hosts the central circadian pacemaker and regulates daily rhythms in physiology and behavior. The SCN is composed of peptidergic neuron populations expressing arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP), as well as glial cells.
Felipe Correa‐da‐Silva, Jari B. Berkhout, Pim Schouten, Margje Sinnema, Constance T. R. M. Stumpel, Leopold M. G. Curfs, Charlotte Höybye, Ahmed Mahfouz, Onno C. Meijer, Alberto M. Pereira, Eric Fliers, Dick F. Swaab, Andries Kalsbeek, Chun‐Xia Yi   +13 more
wiley   +1 more source

Mapping Bullous Emphysema With Lung Ultrasound: A Prospective Multicentre Study

Respirology, EarlyView.
ABSTRACT Background and Objectives Lung ultrasound holds high diagnostic performance for pleural diseases, notably pneumothorax. Bullous emphysema is a potential differential diagnosis of pneumothorax on ultrasound, but its precise semiology is poorly known.
Kinan El Husseini, Thomas Flament, Sophie Laroumagne, Damien Basille, Mathilde Le Brun, Elise Noël‐Savina, Philippe Richard, Gilles Mangiapan, Elise Artaud‐Macari   +8 more
wiley   +1 more source

Limited Risk of Microbial Contamination During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys

Transplant Infectious Disease, EarlyView.
Machine perfusion is increasingly used to preserve donor kidneys. Theoretically, machine perfusion poses as a risk of contamination. We investigated perfusion samples. Our findings show that even though contamination of the perfusate does occur, this did not lead to infectious complications in the recipients.
Julia S. Slagter, Carolina A. M. Schurink, Ga‐Lai M. Chong, Marlies E. J. Reinders, Robert J. Porte, Robert C. Minnee   +5 more
wiley   +1 more source

Aspergillus After Lung Transplantation: Prophylaxis, Risk Factors, and the Impact on Chronic Lung Allograft Dysfunction

Transplant Infectious Disease, EarlyView.
Out of 274 lung transplant (LTx) patients, 89 (32%) developed invasive aspergillosis IA. Factors associated with IA were mycophenolate mofetil use, airway stenosis, Aspergillus cultured pre‐LTx, chronic lung allograft dysfunction (CLAD), and acute rejection. The role of nebulized amphotericin B and statins for prevention of IA remains unclear. ABSTRACT
Johanna P. van Gemert, Ger Jan Fleurke, Onno W. Akkerman, C. Tji. Gan, Willie N. Steenhuis, Huib A. M. Kerstjens, Erik A. M. Verschuuren, Douwe F. Postma   +7 more
wiley   +1 more source