Effects of Aspirin and Prednisone on Platelet Function and Thromboxane Synthesis in Healthy Dogs
Frontiers in Veterinary Science, 2019 Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability. The objective was to determine the effects of sustained aspirin and prednisone
John M. Thomason +3 more
doaj +1 more source
2H-NMR studies of supercooled and glassy aspirin [PDF]
Journal of Non-Crystalline Solids, 353, 3788 (2007), 2007 Acetyl salicylic acid, deuterated at the methyl group, was investigated using 2H-NMR in its supercooled and glassy states. Just above the glass transition temperature the molecular reorientations were studied using stimulated-echo spectroscopy and demonstrated a large degree of similarity with other glass formers.
arxiv +1 more source
Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence [PDF]
Sci Rep 11, 23179 (2021), 2020 Amid the pandemic of 2019 novel coronavirus disease (COVID-19) infected by SARS-CoV-2, a vast amount of drug research for prevention and treatment has been quickly conducted, but these efforts have been unsuccessful thus far. Our objective is to prioritize repurposable drugs using a drug repurposing pipeline that systematically integrates multiple SARS-
arxiv +1 more source
Excited state dynamics of some nonsteroidal anti-inflammatory drugs: a surface-hopping investigation [PDF]
, 2019 Here we present a computational investigation of the excited state dynamics of 5 different active medical substances (aspirin, ibuprofen, carprofen, suprofen, indomethacin) which belong to the family of nonsteroidal anti-inflammatory drugs (NSAIDs). The nonadiabatic dynamics simulations were performed using the surface hopping method, with electronic ...
arxiv +1 more source
The encapsulation of hydrophobic drugs in Pluronic F127 micelles: the effects of drug hydrophobicity, solution temperature and pH [PDF]
Langmuir, 29, 4350 (2013), 2014 Three drugs, Ibuprofen, Aspirin and Erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo- Scanning Electron Microscopy and Dynamic Light Scattering (DLS) experiments, respectively. Uptake of drugs above a
arxiv +1 more source
Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population [PDF]
, 2014 Neurological disorders (Alzheimer’s disease, vascular and mixed dementia) and visual loss (cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy) are among the most common conditions that afflict people of at least 65 years of ...
Caminiti G +13 more
core +1 more source
Low-dose aspirin for primary and secondary prevention of cardiovascular events in Denmark 1998–2018
Scientific Reports, 2021 Randomised controlled trials have shown a neutral or even unfavourable risk–benefit balance of aspirin for primary prevention of cardiovascular events. Using Danish nationwide registries, we investigated aspirin use and associated risks during the past ...
Mikkel B. Christensen +5 more
doaj +1 more source
Thermodynamics of Surface Defects at the Aspirin/Water Interface [PDF]
, 2014 We present a simulation scheme to calculate defect formation free energies at a molecular crystal/water interface based on force-field molecular dynamics (MD) simulations. To this end we adopt and modify existing approaches to calculate binding free energies of biological ligand/receptor complexes to be applicable to common surface defects, such as ...
arxiv +1 more source
Ticagrelor versus clopidogrel after intracranial stent angioplasty: a real-world study
Frontiers in Neurology, 2023 ObjectiveIt was unknown whether a regimen of aspirin plus ticagrelor (aspirin-ticagrelor) attenuates ischemic vascular events without increasing bleeding risk in patients who had undergone intracranial stenting compared with an aspirin plus clopidogrel ...
Lili Sun +9 more
doaj +1 more source
Aspirin-Induced Mortality in AedesaegyptiMosquitoes [PDF]
, 2018 The Aedes aegypti mosquito is a vector for many dangerous diseases including yellow fever, Zika, Chikungunya, and Dengue viruses! Currently, the best method for suppressing infection with these viruses is by controlling their arthropod vectors, however ...
Fischer, Reagan +2 more
core +1 more source