Results 241 to 250 of about 88,633 (281)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Seismic analysis and design of tunnels within fault ground: A review

Deep Underground Science and Engineering, EarlyView.
The research methods of seismic response of tunnels within fault ground, including field investigations, analytical solutions, physical experiments, and numerical simulations, and seismic countermeasures are discussed. The present study examines the shortcomings and limitations of the current research and design, and puts forward proposals for future ...
Xingda Wang, Yujing Jiang, Xuepeng Zhang, Yuyong Jiao, Ningbo Li, Xiao Wang, Bo Li   +6 more
wiley   +1 more source

A Review of Grain Boundaries: Formation Mechanism, Synthesis Strategy, and Application in Electrocatalysis

EcoEnergy, EarlyView.
An overview of grain boundary engineering in the field of electrocatalysis. ABSTRACT Key electrocatalytic reactions such as HER, OER, ORR, CO2RR, and NRR offer promising routes for storing renewable energy as chemical fuels. However, their widespread application is constrained due to the lack of highly active and stable catalysts. Grain boundaries (GBs)
Jingyu Gao, Fengming Zhou, Xinying Li, Ying Deng, Zexing Wu, Siyuan Feng, Yujing Zhu, Dan Zhang, Zhenyu Xiao   +8 more
wiley   +1 more source

Thrombo-inflammation and Rethinking the Role of Aspirin in Kawasaki Disease. [PDF]

Curr Rheumatol Rep
Kocatürk B, Berberoğulları B, Aliyev E, Sağ E, Özen S, Arditi M.   +5 more
europepmc   +1 more source

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Aspirin resistance

Lancet, The, 2006
Describes the concept, mechanisms, adverse clinical events, and treatment of aspirin resistance as related to coronary arterial thrombosis.
Graeme J Hankey, John W Eikelboom
exaly   +14 more sources

Mechanisms of aspirin resistance

Pharmacology & Therapeutics, 2014
Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
Christopher N Floyd, Albert Ferro
exaly   +4 more sources

Aspirin resistance

Thrombosis Research, 2007
Aspirin resistance refers to less than expected suppression of thromboxane A(2) production by aspirin and has been reported to be independently associated with an increased risk of adverse cardiovascular events. Possible causes of aspirin resistance include poor compliance, drug interaction, inadequate aspirin dose, increase turnover of platelets ...
Huyen A, Tran, Sonia S, Anand, Graeme J, Hankey, John W, Eikelboom   +3 more
openaire   +4 more sources

Lack of aspirin effect: aspirin resistance or resistance to taking aspirin?

American Heart Journal, 2004
A lack of aspirin effect on platelets after a myocardial infarction (MI) is associated with poor health outcome. This lack of effect may be due to biological resistance to aspirin or due to nonadherence (the patient is not taking the aspirin, hence it has no effect).
Gad, Cotter, Eyal, Shemesh, Miriam, Zehavi, Irit, Dinur, Abraham, Rudnick, Olga, Milo, Zvi, Vered, Rikardo, Krakover, Edo, Kaluski, Abraham, Kornberg   +9 more
openaire   +2 more sources

Aspirin resistance: An update

Current Atherosclerosis Reports, 2009
Aspirin resistance (AR) still lacks a universally accepted definition, but it may be discussed as either a laboratory phenomenon or a clinical presentation. Laboratory resistance is mainly defined as abnormal platelet response to aspirin, whereas the clinical manifestation is the failure of aspirin to prevent cardiovascular events.
Gilead I, Lancaster, Janardhan, Srinivasan, Hitender, Jain   +2 more
openaire   +2 more sources

Aspirin and Clopidogrel Resistance

Hematology, 2007
AbstractAspirin and clopidogrel provide significant clinical benefit in patients with cardiovascular disease. However, given the complexity of platelet activation, it is not surprising that aspirin or clopidogrel prevent a small proportion of cardiovascular events.
Desmond J, Fitzgerald, Andrew, Maree
openaire   +2 more sources