Results 61 to 70 of about 150,528 (281)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Diving deep into digital literacy:emerging methods for research [PDF]

, 2015
Literacy studies approaches have tended to adopt a position which enables ethnographic explorations of a wide range of ‘literacies’. An important issue arising is the new challenge required for researchers to capture, manage, and analyse data that ...
Albers P., Barthes R., Barton D., Baynham M., Bhatt I., Bhatt I., Black R.W., Cope B., Dyson A.H., Gee J.P., Gee J.P., Gilmore P., Gilster P., Goffman E., Gourlay L., Hamilton M., Heath C., Heath S.B., Heath S.B., Ibrar Bhatt, Ivanič R., Jenkins H., Jonathon Adams, Kalantzis M., Lankshear C., Law J., Leander K., Norris S., Pahl K., Paynton S., Rheingold H., Roberto de Roock, Snee H., Snyder I., Spiers J.A., Street B.V., Street B.V., Wortham S.   +37 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Integrating Course Material and Application: A Progressive Writing Assignment Applied to an Astrochemistry Tutorial

Prompt, 2018
A major challenge in teaching is helping students integrate course concepts to understand the big picture of a field and apply those concepts in new situations.
Olivia H. Wilkins, Camillus F. Buzard
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Writing for Nonprofits in a Professionally-Oriented Institution: Using Rhetorical Genre Studies to Teach Flexibility

Prompt, 2019
Teaching rhetorical flexibility within a nonprofit environment to professionally-oriented students can be challenging because the seemingly transactional genres of nonprofit communication, such as grant applications, do not appear to invite improvisation.
Kathryn J. Gindlesparger
doaj   +1 more source

The opinion podcast: A visceral form of persuasion

Prompt, 2020
In this assignment, students create a podcast episode in which they make an argument on a topic in current events. Through this process, students develop traditional rhetorical skills such as awareness of audience, formulation of a thesis, and inclusion ...
Alison Klein
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Using Content Reading Assignments in a Psychology Course to Teach Critical Reading Skills

Journal of the Scholarship of Teaching and Learning, 2012
Liberal arts students are expected to graduate college with fully developed critical reading and writing skills. However, for a variety of reasons these skills are not always as well developed as they might be - both during and upon completion of college.
Debbie Van Camp, Wesley Van Camp
doaj  

Composing Comes Alive: Dramatic Presentations in the Writing Classroom

Prompt, 2019
In creating and presenting a collaborative dramatic presentation of a literary text, composition students bring "The Yellow Wallpaper" to life through close reading, literary analysis and synthesis, recursive multi-modal writing, and group performance ...
Ann E. Wallace
doaj   +1 more source