Results 31 to 40 of about 9,404,323 (308)

Imprinting and assisted reproductive technology [PDF]

Human Molecular Genetics, 2005
In the past 25 years, the frequency of assisted reproductive technology (ART) births has increased rapidly to account for 1-2% of all births in many developed countries. ART procedures such as in vitro fertilization and intracytoplasmic sperm injection are generally considered to be safe, but recent studies suggest a small excess of birth defects and ...
openaire   +2 more sources

Beyond the Document: A Single‐Center Qualitative Study of Survivorship Care Plan Barriers and Opportunities Across Pediatric Oncology Stakeholders

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivorship care plans (SCPs) summarize cancer treatment and guide risk‐based follow‐up for cancer survivors, yet remain difficult to create, share, and use. Stakeholder perspectives are needed to inform usable approaches.
Molly S. Talman, Emma Fleisher, Megan E. Salwei, Debra Friedman, Laurie Novak   +4 more
wiley   +1 more source

The pan-cancer landscape of abnormal DNA methylation and intratumor microorganisms

Neoplasia: An International Journal for Oncology Research, 2023
Microorganisms play very important roles in carcinogenesis, tumor progression, and resistance upon treatment. Due to the challenge of accurately acquiring samples and quantifying low-biomass tissue microorganisms, most studies have focused on the effect ...
Ping Zhou, Simon L. Lu, Liang Chang, Baoying Liao, Ming Cheng, Xiaolin Xu, Xin Sui, Fenting Liu, Mingshu Zhang, Yinxue Wang, Rui Yang, Rong Li, Heng Pan, Chao Zhang   +13 more
doaj   +1 more source

Epigenetic changes and assisted reproductive technologies [PDF]

Epigenetics, 2019
Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific procedures used in ART or biological factors that are intrinsic to infertility has been the subject of much debate, as has the mechanism
Sneha Mani, Jayashri Ghosh, Christos Coutifaris, Carmen Sapienza, Monica Mainigi   +4 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome

Journal of Nanobiotechnology, 2023
The immune system is closely associated with the pathogenesis of polycystic ovary syndrome (PCOS). Macrophages are one of the important immune cell types in the ovarian proinflammatory microenvironment, and ameliorate the inflammatory status mainly ...
Sisi Yan, Zhipeng Gao, Jinli Ding, Suming Chen, Zehao Wang, Wenyi Jin, Bing Qu, Yi Zhang, Lian Yang, Duanying Guo, Tailang Yin, Yanbing Yang, Yan Zhang, Jing Yang   +13 more
doaj   +1 more source

The Influence of the Vanishing Twin on the Perinatal Outcome of Surviving Singleton in IVF Pregnancy

Frontiers in Endocrinology, 2022
ObjectiveThe purpose of this study was to clarify the influence of the vanishing twin (VT) on the perinatal outcomes in the surviving singleton and further identify the susceptible window.Study designRetrospective cohort study.MethodsA total of 636 ...
Jiarong Li, Jiarong Li, Jiarong Li, Jiarong Li, Jiarong Li, Jiarong Li, Jingyu Li, Jingyu Li, Jingyu Li, Jingyu Li, Jingyu Li, Jingyu Li, Yiyuan Zhang, Yiyuan Zhang, Yiyuan Zhang, Yiyuan Zhang, Yiyuan Zhang, Yiyuan Zhang, Kuona Hu, Kuona Hu, Kuona Hu, Kuona Hu, Kuona Hu, Kuona Hu, Na Chen, Na Chen, Na Chen, Na Chen, Na Chen, Na Chen, Jie Gao, Jie Gao, Jie Gao, Jie Gao, Jie Gao, Jie Gao, Jingmei Hu, Jingmei Hu, Jingmei Hu, Jingmei Hu, Jingmei Hu, Jingmei Hu, Linlin Cui, Linlin Cui, Linlin Cui, Linlin Cui, Linlin Cui, Linlin Cui, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen   +55 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Roles of Mitochondrial SIRT4 in Cellular Metabolism

Frontiers in Endocrinology, 2019
Sirtuins comprise a family of nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases that regulate the life span, aging, and metabolism. Seven sirtuin family members (SIRT1-7) have been identified in mammals, including humans.
Zheying Min, Zheying Min, Jiangman Gao, Yang Yu   +3 more
doaj   +1 more source