Results 51 to 60 of about 209,899 (291)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Associative Learning in Invertebrates [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
This work reviews research on neural mechanisms of two types of associative learning in the marine mollusk Aplysia, classical conditioning of the gill- and siphon-withdrawal reflex and operant conditioning of feeding behavior. Basic classical conditioning is caused in part by activity-dependent facilitation at sensory neuron-motor neuron (SN-MN ...
Robert D, Hawkins, John H, Byrne
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Vicarious reward unblocks associative learning about novel cues in male rats

eLife, 2020
Many species, including rats, are sensitive to social signals and their valuation is important in social learning. Here we introduce a task that investigates if mutual reward delivery in male rats can drive associative learning.
Sander van Gurp, Jochen Hoog, Tobias Kalenscher, Marijn van Wingerden   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Non-associative learning underlies pollination interaction of pollinators and flowering plants

National Science Open
The behavioral response of pollinators is significantly influenced by the prior experience of flower visiting. Learning of pollinators, including non-associative learning, associative learning, and operant conditioning, is determined by the presence or ...
Zhang Wu-Fan, Luo Yi-Bo
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Synapse Innervation and Associative Memory Cell Are Recruited for Integrative Storage of Whisker and Odor Signals in the Barrel Cortex through miRNA-Mediated Processes

Frontiers in Cellular Neuroscience, 2017
Associative learning is a common way for information acquisition, and the integrative storage of multiple associated signals is essential for associative thinking and logical reasoning.
Zhuofan Lei, Zhuofan Lei, Zhuofan Lei, Dangui Wang, Na Chen, Ke Ma, Wei Lu, Wei Lu, Zhenhua Song, Shan Cui, Jin-Hui Wang, Jin-Hui Wang, Jin-Hui Wang   +12 more
doaj   +1 more source

The pigeon as a machine: Complex category structures can be acquired by a simple associative model

iScience, 2023
Summary: Never known for its smarts, the pigeon has proven to be a prodigious classifier of complex visual stimuli. What explains its surprising success? Does it possess elaborate executive functions akin to those deployed by humans?
Brandon M. Turner, Edward A. Wasserman
doaj   +1 more source

Associative concept learning in animals [PDF]

Journal of the Experimental Analysis of Behavior, 2013
Nonhuman animals show evidence for three types of concept learning: perceptual or similarity‐based in which objects/stimuli are categorized based on physical similarity; relational in which one object/stimulus is categorized relative to another (e.g., same/different); and associative in which arbitrary stimuli become interchangeable with one another by
Zentall, Thomas R, Wasserman, Edward A, Urcuioli, Peter J   +2 more
openaire   +4 more sources