Results 41 to 50 of about 6,400,099 (241)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Non-associative learning underlies pollination interaction of pollinators and flowering plants
National Science OpenThe behavioral response of pollinators is significantly influenced by the prior experience of flower visiting. Learning of pollinators, including non-associative learning, associative learning, and operant conditioning, is determined by the presence or ...
Zhang Wu-Fan, Luo Yi-Bo
doaj +1 more source
Associative learning of concepts
Computer Assisted Methods in Engineering and Science, 2022 Humans find it extremely easy to say if two words are related or if one word is more related to a given word than another one. For example, if we come across two words - 'car' and 'bicycle', we know they are related since both are means of transport ...
Viliam Rockai, Robert Kende
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The pigeon as a machine: Complex category structures can be acquired by a simple associative model
iScience, 2023 Summary: Never known for its smarts, the pigeon has proven to be a prodigious classifier of complex visual stimuli. What explains its surprising success? Does it possess elaborate executive functions akin to those deployed by humans?
Brandon M. Turner, Edward A. Wasserman
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Retrospective revaluation as simple associative learning [PDF]
, 2005 Backward blocking, unovershadowing and backward conditioned inhibition are examples of "retrospective revaluation" phenomena, that have been suggested to involve more than simple associative learning.
Ghirlanda, Stefano
core +1 more source
Vicarious reward unblocks associative learning about novel cues in male rats
eLife, 2020 Many species, including rats, are sensitive to social signals and their valuation is important in social learning. Here we introduce a task that investigates if mutual reward delivery in male rats can drive associative learning.
Sander van Gurp +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source