Results 61 to 70 of about 209,899 (291)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Adaptive Resonance Associative Map: A Hierarchical ART System for Fast Stable Associative Learning [PDF]

open access: yes, 1992
This paper introduces a new class of predictive ART architectures, called Adaptive Resonance Associative Map (ARAM) which performs rapid, yet stable heteroassociative learning in real time environment.
Tan, Ah-Hwee
core   +1 more source

Population-based incremental learning with associative memory for dynamic environments [PDF]

open access: yes, 2008
Copyright © 2007 IEEE. Reprinted from IEEE Transactions on Evolutionary Computation. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's ...
Yang, S, Yao, X
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Dynamical model of sequential spatial memory: winnerless competition of patterns

open access: yes, 2002
We introduce a new biologically-motivated model of sequential spatial memory which is based on the principle of winnerless competition (WLC). We implement this mechanism in a two-layer neural network structure and present the learning dynamics which ...
A. Samsonovich   +20 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Creativity supports learning through associative thinking

open access: yesnpj Science of Learning
Creativity is a key 21st-century skill and a consistent predictor of academic learning outcomes. Despite decades of research on creativity and learning, little is known about the cognitive mechanisms underlying their relationship.
Simone A. Luchini   +8 more
doaj   +1 more source

Parallel encoding of sensory history and behavioral preference during Caenorhabditis elegans olfactory learning

open access: yeseLife, 2016
Sensory experience modifies behavior through both associative and non-associative learning. In Caenorhabditis elegans, pairing odor with food deprivation results in aversive olfactory learning, and pairing odor with food results in appetitive learning ...
Christine E Cho   +3 more
doaj   +1 more source

Social learning through associative processes: a computational theory [PDF]

open access: yesRoyal Society Open Science, 2019
Social transmission of information is a key phenomenon in the evolution of behaviour and in the establishment of traditions and culture. The diversity of social learning phenomena has engendered a diverse terminology and numerous ideas about underlying ...
Johan Lind   +2 more
doaj   +1 more source

Learning by Association in Plants [PDF]

open access: yesScientific Reports, 2016
Abstract In complex and ever-changing environments, resources such as food are often scarce and unevenly distributed in space and time. Therefore, utilizing external cues to locate and remember high-quality sources allows more efficient foraging, thus increasing chances for survival.
Gagliano, Monica   +4 more
openaire   +4 more sources

Home - About - Disclaimer - Privacy