Results 61 to 70 of about 6,400,099 (241)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Associative memory cells and their working principle in the brain [version 1; referees: 2 approved]

F1000Research, 2018
The acquisition, integration and storage of exogenous associated signals are termed as associative learning and memory. The consequences and processes of associative thinking and logical reasoning based on these stored exogenous signals can be memorized ...
Jin-Hui Wang, Shan Cui
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Prediction error dependent changes in brain connectivity during associative learning [PDF]

, 2009
One of the fundaments of associative learning theories is that surprising events drive learning by signalling the need to update one’s beliefs. It has long been suggested that plasticity of connection strengths between neurons underlies the learning ...
den Ouden, H.E.M.
core  

Associative memory advantage in grapheme-colour synaesthetes compared to older, but not younger adults

Frontiers in Psychology, 2014
People with grapheme-colour synaesthesia perceive enriched experiences of colours in response to graphemes (letters, digits). In this study, we examined whether these synaesthetes show a generic associative memory advantage for stimuli that do not elicit
Gaby ePfeifer, Nicolas eRothen, Jamie eWard, Dennis eChan, Natasha eSigala   +4 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

grillfilip/Dopamine-release-in-human-associative-striatum-during-reversal-learning: Imaging data

, 2023
<p><strong>Full Changelog</strong>: https://github.com/grillfilip/Dopamine-release-in-human-associative-striatum-during-reversal-learning/compare/Imagingdata...NatComReleaseImaging</p ...
grillfilip
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

ROLES OF DISTINCT AMYGDALAR PARVALBUMIN INTERNEURON TYPES IN REGULATING FEAR AND ANXIETY

IBRO Neuroscience Reports, 2023
Cloé Lheraux, Amélie Maurel, Petra Nagy-Pal, Yann Humeau, Norbert Hajos, Cyril Herry, Frederic Lanore, Thomas Bienvenu   +7 more
doaj   +1 more source