Results 41 to 50 of about 789,460 (209)

Asthma phenotypes and IgE responses [PDF]

European Respiratory Journal, 2015
The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy. Novel facets of the complex link between IgE and asthma have been highlighted by the effect of this treatment and by basic research.
Antoine, Froidure, Jonathan, Mouthuy, Stephen R, Durham, Pascal, Chanez, Yves, Sibille, Charles, Pilette   +5 more
openaire   +2 more sources

Phenotype of asthma related with high serum periostin levels

Allergology International, 2015
Background: Asthma is a heterogeneous disease composed of various phenotypes. Periostin, a molecule inducible with interleukin (IL)-4 or IL-13 in bronchial epithelial cells, is a biomarker of “TH2-high” asthma.
Masako Matsusaka, Hiroki Kabata, Koichi Fukunaga, Yusuke Suzuki, Katsunori Masaki, Takao Mochimaru, Fumio Sakamaki, Yoshitaka Oyamada, Takashi Inoue, Tsuyoshi Oguma, Koichi Sayama, Hidefumi Koh, Morio Nakamura, Akira Umeda, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Koichiro Asano, Tomoko Betsuyaku   +18 more
doaj   +1 more source

Abrupt withdrawal of inhaled corticosteroids does not result in spirometric deterioration in chronic obstructive pulmonary disease: Effect of phenotyping?

Annals of Thoracic Medicine, 2012
Background and Objective: Some studies show a decline of FEV 1 only one month after withdrawal of inhaled corticosteroids (ICS), while others show no decline.
Feisal A Al-Kassimi, Esam H Alhamad, Mohammed S Al-Hajjaj, Abdullah A Abba, Emad Raddaoui, Shaffi A Shaikh   +5 more
doaj   +1 more source

A modern approach to identifying and characterizing child asthma and wheeze phenotypes based on clinical data.

PLoS ONE, 2019
'Asthma' is a complex disease that encapsulates a heterogeneous group of phenotypes and endotypes. Research to understand these phenotypes has previously been based on longitudinal wheeze patterns or hypothesis-driven observational criteria.
Bronwyn K Brew, Flaminia Chiesa, Cecilia Lundholm, Anne Örtqvist, Catarina Almqvist   +4 more
doaj   +1 more source

A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children

Biomedicines, 2020
Background: Asthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to
Mª Amelia Gomez-Llorente, Ana Martínez-Cañavate, Natalia Chueca, Mª de la Cruz Rico, Raquel Romero, Augusto Anguita-Ruiz, Concepción Mª Aguilera, Mercedes Gil-Campos, Maria D Mesa, Bekzod Khakimov, Jose Antonio Morillo, Ángel Gil, José Camacho, Carolina Gomez-Llorente   +13 more
doaj   +1 more source

Differential Contributions of Inhalant and Food Allergen Sensitization to Atopic Phenotype Asthma Prevalence among Children across Age Groups

Pediatric Respirology and Critical Care Medicine
Background: Allergen sensitization is a critical factor in pediatric asthma development, yet the relative contributions of inhalant and food allergens across age groups remain poorly defined.
Yu-Cheng Tsai, Ya-Ling Huang, Ping-Hsuan Hsieh, Yu-Shen Chen, Ting-I Lin, Ching-Chung Tsai, Yu-Tsun Su   +6 more
doaj   +1 more source

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma [PDF]

, 2013
Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances the ...
Donna E Davies, Cornelius Victoria, Grégory Seumois, Lau, LC, Karl J Staples, Cornelius, Victoria, Dorinsky, P, Victoria Cornelius, Davies Donna E., Dinesh Bagmane (457229), Staples, Karl J., Uddin, Mohib, Ratko Djukanović, Pandurangan Vijayanand, Victoria Cornelius (457230), Lau, Laurie C., Mohib Uddin (457226), Karl J. Staples (457228), Bagmane, Dinesh, Ratko Djukanović (457232), Paul Dorinsky, Pandurangan Vijayanand (277869), Djukanović Ratko, Lau, Laurie C, Grégory Seumois (5656213), Lau Laurie C., Staples, KJ, Vijayanand, P, Vijayanand, Pandurangan, Laurie C. Lau (457227), Seumois, G, Uddin, M, Staples, Karl J, Davies, Donna E, Staples Karl J., Davies, DE, Donna E. Davies (137702), Seumois Grégory, Djukanović, R, Dinesh Bagmane, Djukanović, Ratko, Cornelius, V, Davies, Donna E., Laurie C Lau, Dorinsky Paul, Paul Dorinsky (457231), Dorinsky, Paul, Seumois, Grégory, Bagmane Dinesh, Uddin Mohib, Bagmane, D, Mohib Uddin, Vijayanand Pandurangan   +52 more
core   +2 more sources

SEVERE ASTHMA IN CHILDREN

RUDN Journal of Medicine, 2018
The definition of severe asthma is based on the criteria for clinical control, the treatment received, as well as the response to therapy, the assessment of future risk.
T R Stroikova, O A Bashkina, Yu L Mizernitskiy, E N Seliverstova   +3 more
doaj   +1 more source

T-bet syndrome-associated bronchial asthma phenotype

Медицинская иммунология, 2020
We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people).
L. N. Sorokina, V. N. Mineev, A. V. Eremeeva, M. A. Nyoma   +3 more
doaj   +1 more source

Different Airway Inflammatory Phenotypes Correlate with Specific Fungal and Bacterial Microbiota in Asthma and Chronic Obstructive Pulmonary Disease

Journal of Immunology Research, 2022
Background. Studies of chronic airway inflammatory diseases have increasingly focused on airway microbiota. However, the microbiota characteristics of asthma and chronic obstructive pulmonary disease (COPD) patients with different airway inflammatory ...
Rui Yang, Qiao Zhang, Zhidong Ren, Hong Li, Qianli Ma   +4 more
doaj   +1 more source