Results 141 to 150 of about 283,599 (345)

Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation

Journal of Neuroinflammation
One of the histopathological hallmarks of neuroinflammatory diseases such as multiple sclerosis (MS) is the emergence of astrocyte reactivity. Accumulating evidence suggests that excessive glycolysis may lead to astrocyte reactivity and contribute to ...
Luting Yang, Chunqing Hu, Xiaowen Chen, Mengru Sun, Jie Zhang, Zhe Feng, Tingting Cui, Ruyi Zhu, Xin Zhang, Yanxin Xiao, Ye Gong, Yang Yang, Qian Zhang, Yaling Zhang, Yaping Yan   +14 more
doaj   +1 more source

High-throughput continuous dielectrophoretic separation of neural stem cells. [PDF]

, 2019
We created an integrated microfluidic cell separation system that incorporates hydrophoresis and dielectrophoresis modules to facilitate high-throughput continuous cell separation. The hydrophoresis module consists of a serpentine channel with ridges and
Adams, Tayloria NG, Aghaamoo, Mohammad, Flanagan, Lisa A, Jiang, Alan YL, Lee, Abraham P, Lee, Do-Hyun, Yale, Andrew R   +6 more
core   +1 more source

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

Cell Death and Disease, 2019
Although multiple hypotheses had been proposed to clarify the causes of depression, the accurate pathogenesis and effective treatment of depression still need to be solved.
Xiao-dong Shu, Yiming Sun, Xiyang Sun, Yuanzhang Zhou, Y. Bian, Zhaoma Shu, Jian-hua Ding, Ming Lu, G. Hu   +8 more
semanticscholar   +1 more source

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Journal of Neuroinflammation
Background Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuroprotective activities.
Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma, Ren-Hong Du   +8 more
doaj   +1 more source

NEURON-GLIA NETWORKS: INTEGRAL GEAR OF BRAIN FUNCTION

Frontiers in Cellular Neuroscience, 2014
Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and homeostatic functions of the Nervous System; however, their participation in coding information and cognitive processes has been largely ignored.
Gertrudis ePerea, Mriganka eSur, Alfonso eAraque   +2 more
doaj   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source

Revisiting Ferroelectric‐Gated Phototransistors: A Tripartite Synapse‐Inspired Approach to In‐Sensor Image Processing

Advanced Materials, EarlyView.
A ferroelectric‐gated phototransistor (FGPT) enables linear and multilevel modulation of photoconductance through partial polarization switching and photogating effects. The device achieves photonic non‐volatility over a 153 dB dynamic range and performs in‐sensor processing under unstructured illumination, demonstrating enhanced face recognition ...
Yubin Lee, Dong Hyun Seo, Jun Seo Lee, Jae Min Jeon, Hyung Rae Kim, Min Seok Kim, Chaehyeon Ahn, Sung‐Un An, Jihun Choi, Hyunseung Kim, Chang Kyu Jeong, Hyunseob Lim, Dong‐Ho Kang, Young Min Song   +13 more
wiley   +1 more source

Ca²⁺‐dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β‐treated astrocytes and in a model of Alzheimer's disease [PDF]

, 2013
Elena Alberdi, Ane Wyssenbach, María Alberdi, María Victoria Sánchez‐Gómez, Fabio Cavaliere, José J. Rodrı́guez, Alexei Verkhratsky, Carlos Matute   +7 more
openalex   +1 more source

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

Scientific Reports, 2019
Astrocyte reactivation has been discovered to be an important contributor to several neurological diseases. In vitro models involving human astrocytes have the potential to reveal disease-specific mechanisms of these cells and to advance research on ...
Tanja Hyvärinen, S. Hagman, Mervi Ristola, Lassi Sukki, Katariina Veijula, J. Kreutzer, P. Kallio, S. Narkilahti   +7 more
semanticscholar   +1 more source