Results 151 to 160 of about 194,703 (370)

Three-dimensional Ca2+ imaging advances understanding of astrocyte biology

open access: yesScience, 2017
Glial calcium dynamics in space and time Astrocytes use calcium signals to process information received from neighboring brain cells and thus generate modulatory responses at the local or network level.
Erika Bindocci   +5 more
semanticscholar   +1 more source

Astrocytes and Tinnitus

open access: yesBrain Sciences
Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based on maladaptive plasticity mechanisms. Astrocytes play a major role in both neural responses to inflammation and plasticity regulation; moreover, they have ...
Paola Perin, Roberto Pizzala
openaire   +2 more sources

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi   +11 more
wiley   +1 more source

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

open access: yesScientific Reports, 2019
Astrocyte reactivation has been discovered to be an important contributor to several neurological diseases. In vitro models involving human astrocytes have the potential to reveal disease-specific mechanisms of these cells and to advance research on ...
Tanja Hyvärinen   +7 more
semanticscholar   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

open access: yesAdvanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Opioid-Mediated Astrocyte–Neuron Signaling in the Nucleus Accumbens

open access: yesCells, 2019
Major hallmarks of astrocyte physiology are the elevation of intracellular calcium in response to neurotransmitters and the release of neuroactive substances (gliotransmitters) that modulate neuronal activity.
Michelle Corkrum   +4 more
doaj   +1 more source

Astrocyte Heterogeneity in the Adult Central Nervous System

open access: yesFrontiers in Cellular Neuroscience, 2018
Astrocytes are the most abundant cell type in the central nervous system (CNS), providing critical roles in the overall maintenance and homeostasis.
Sean J. Miller
semanticscholar   +1 more source

scHeteroNet: A Heterophily‐Aware Graph Neural Network for Accurate Cell Type Annotation and Novel Cell Detection

open access: yesAdvanced Science, EarlyView.
scHeteroNet) is a novel graph neural network model that explicitly addresses heterophily in single‐cell sequencing data enabling accurate cell type annotation and novel cell type discovery. By leveraging heterophily‐aware message passing and novelty propagation mechanisms, scHeteroNet achieves superior performance in both cell annotation and detection ...
Jiacheng Liu   +7 more
wiley   +1 more source

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