Results 101 to 110 of about 303,608 (351)

Astrocytes are necessary for blood-brain barrier maintenance in the adult mouse brain

open access: yesbioRxiv, 2020
In the adult brain, multiple cell types are known to produce factors that regulate blood-brain barrier properties, including astrocytes. Yet several recent studies disputed a role for mature astrocytes at the blood-brain barrier.
Benjamin P. Heithoff   +5 more
semanticscholar   +1 more source

Bicontinuous Microarchitected Scaffolds Provide Topographic Cues That Govern Neuronal Behavior and Maturation

open access: yesAdvanced Functional Materials, EarlyView.
A scalable biomimetic platform transforms bioinert poly(ethylene glycol) diacrylate into neuroinstructive matrices via integrating solvent transfer‐induced phase separation, microfluidics, and 3D bioprinting. Bicontinuous, hyperbolically curved microporous networks embedded within a fibrous construct elicit rapid adhesion, robust proliferation, and ...
Prince D. Okoro   +8 more
wiley   +1 more source

Astrocytes in the Epileptic Brain [PDF]

open access: yesNeuron, 2008
The roles that astrocytes play in the evolution of abnormal network excitability in chronic neurological disorders involving brain injury, such as acquired epilepsy, are receiving renewed attention due to improved understanding of the molecular events underpinning the physiological functions of astrocytes.
Geidy Serrano   +2 more
openaire   +3 more sources

Polymer‐Incorporated Mechanically Compliant Carbon Nanotube Microelectrode Arrays for Multichannel Neural Signal Recording

open access: yesAdvanced Functional Materials, EarlyView.
This work presents a soft microelectrode array based on vertically aligned carbon nanotube (CNT) forests, combining high conductivity with mechanical softness. A densification process and air‐pressure‐assisted flexibilization improve structural integrity, ensuring stable insertion and reduced inflammation.
Hyeonhee Roh   +8 more
wiley   +1 more source

PHLPP1 regulates region-specific astroglial mitochondrial fission in response to oxidative stress in the male rat hippocampus

open access: yesScientific Reports
Astrocytes have specialized functions depending on their localization. This region-dependent heterogeneity of astrocytes shows marked difference in astroglial responses to various stimuli.
Ji-Eun Kim   +2 more
doaj   +1 more source

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

open access: yesStem Cell Reports, 2019
Summary: Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous contribution, in particular of astrocytes, during PD pathogenesis has
Angelique di Domenico   +16 more
doaj   +1 more source

Protective Functions of Reactive Astrocytes Following Central Nervous System Insult

open access: yesFrontiers in Immunology, 2020
Astrocytes play important roles in numerous central nervous system disorders including autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis, ischemic stroke, and Alzheimer’s disease. Depending on the spatial and temporal
M. Linnerbauer, Veit Rothhammer
semanticscholar   +1 more source

Highly Customizable Scaffold‐Type 3D Microelectrode Array Platform for Design and Analysis of the 3D Neuronal Network In Vitro

open access: yesAdvanced Functional Materials, EarlyView.
An innovative fabrication platform for 3D microelectrode arrays (MEAs) is presented, utilizing a 3D printer and the capillary action of electrically conductive inks. This approach enables the simple and versatile fabrication of 3D MEAs with complex structures.
Dongjo Yoon, Yoonkey Nam
wiley   +1 more source

Memory in astrocytes: a hypothesis [PDF]

open access: yesTheoretical Biology and Medical Modelling, 2006
AbstractBackgroundRecent work has indicated an increasingly complex role for astrocytes in the central nervous system. Astrocytes are now known to exchange information with neurons at synaptic junctions and to alter the information processing capabilities of the neurons.
openaire   +3 more sources

Quick Access to Human Astrocytic Software that Drives Neuronal Hardware

open access: yesStem Cell Reports, 2018
Astrocytes have important functions in the brain and their deregulation may cause disease. Current ways to derive astrocytes from pluripotent stem cells are labor, time, and resource intensive, but in this issue of Stem Cell Reports, Li et al.
Anders Lundin, Anna Falk
doaj   +1 more source

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