Results 121 to 130 of about 249,621 (311)
Advanced Functional Materials, EarlyView.A biomimetic aerogel conduit was engineered from a nanofiber of gelatin/poly(l‐lactic acid) doped with polypyrrole nanoparticles, integrated with tannic acid and Mg2+. This “electro‐ionic‐immune” strategy mimicked spinal cord properties, reduced calcium overload, inflammation, oxidative damage, promoted neural stem cell differentiation, suppressed ...
Qingxiang Liu +9 more
wiley +1 more source
A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles [PDF]
Extracellular vesicles (EVs) are secreted by all cells in the CNS, including neurons and astrocytes. EVs are lipid membrane enclosed particles loaded with various bioactive cargoes reflecting the dynamic activities of cells of origin.
Serres, Sébastien +17 more
core +1 more source
The spectrum of Ischemia-induced white matter injury varies with age [PDF]
, 2013 Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Zammit, Christian +2 more
core +1 more source
A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses
Advanced Healthcare Materials, EarlyView.This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang +16 more
wiley +1 more source
Copper metabolism and copper-mediated alterations in the metabolism of cultured astrocytes [PDF]
, 2012 Copper is an essential element that is required for a variety of important cellular functions. Since not only copper deficiency, but also excess of copper can seriously affect cellular functions, cellular copper metabolism is tightly regulated ...
Scheiber, Ivo Florin
core
General anesthetic agents induce neurotoxicity through astrocytes
Neural Regeneration ResearchNeuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters.
Yanchang Yang +10 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang +4 more
wiley +1 more source
The role of glia in protein misfolding diseases [PDF]
, 2010 The astrocytes, oligodendrocytes and microglia make up a significant proportion of the cells of the CNS. In recent years, there has been a burgeoning interest in the role of glial cells, in neurodegenerative disease.
Samson, Ben
core
Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes [PDF]
, 2009 Accumulating evidence indicates that agrin, a heparan sulphate proteoglycan of the extracellular matrix, plays a role in the organization and maintenance of the blood-brain barrier.
Noell, Susan +4 more
core +1 more source