Results 131 to 140 of about 123,114 (319)
Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes
Frontiers in Cellular Neuroscience, 2019 CD73, an ectonucleotidase, participates in the regulation of immune responses by controlling the conversion of extracellular AMP to adenosine. In this study, we investigated whether any type of brain cells, especially neuroglia cells, exhibit altered ...
Shumin Zhou +5 more
doaj +1 more source
Advanced Science, EarlyView.Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai +14 more
wiley +1 more source
Journal of Pharmacological Sciences, 2020 The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi +3 more
doaj
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Function and therapeutic value of astrocytes in neurological diseases
Nature reviews. Drug discovery, 2022 Hong-Gyun Lee +2 more
semanticscholar +1 more source
The Role of Astrocytes in Multiple Sclerosis
Frontiers in Immunology, 2018 The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS) lesions has been the formation of the glial scar once inflammation has subsided.
G. Ponath, Calvin Park, D. Pitt
semanticscholar +1 more source
Hydrogen Peroxide-Induced Thymidine Incorporation Into Cultured Rat Astrocytes
Journal of Pharmacological Sciences, 2006 We characterized [methyl-3H]thymidine ([3H]thymidine) and [5-3H]uridine ([3H]uridine) incorporation into cultured astrocytes and neurons in the presence and absence of hydrogen peroxide (H2O2) in order to define the response to oxidative stress in the ...
Koh-ichi Tanaka +3 more
doaj
Nanotherapy for Neural Retinal Regeneration
Advanced Science, EarlyView.Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu +11 more
wiley +1 more source
An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells
Stem Cell Reports, 2017 Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Julia TCW +13 more
doaj
iScience, 2022 Summary: Much of what we know about astrocyte form and function is derived from the study of gray matter protoplasmic astrocytes, whereas white matter fibrous astrocytes remain relatively unexplored. Here, we used the ribotag approach to isolate ribosome-
Arpan G. Mazumder +3 more
doaj