Results 191 to 200 of about 123,114 (319)

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Aim The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects.
Huan Liu   +6 more
wiley   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

open access: yesAdvanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li   +11 more
wiley   +1 more source

Preparation of gastrodin‐modified dendrimer‐entrapped gold nanoparticles as a drug delivery system for cerebral ischemia–reperfusion injury

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Objective This study sought to evaluate the feasibility of multifunctional gastrodin (GAS)‐containing nano‐drug carrier system against cerebral ischemia–reperfusion injury (CIRI). Methods The drug‐loaded nanocomposite (Au‐G5.NHAc‐PS/GAS) with certain encapsulation efficiency (EE) was prepared by physical adsorption method using different ...
Wenqiang Huang   +8 more
wiley   +1 more source

Neurotoxic reactive astrocytes are induced by activated microglia

open access: yesNature, 2017
S. A. Liddelow   +20 more
semanticscholar   +1 more source

The Role of Astrocytes in CNS Inflammation.

open access: yesTrends in immunology, 2020
Federico Giovannoni, F. Quintana
semanticscholar   +1 more source

Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner

open access: yesBiological Psychiatry Global Open Science
Background: Development of synaptic activity is a key neuronal characteristic that relies largely on interactions between neurons and astrocytes. Although astrocytes have known roles in regulating synaptic function and malfunction, the use of human- or ...
Noora Räsänen   +11 more
doaj  

Firing rate model for brain rhythms controlled by astrocytes [PDF]

open access: yesarXiv
We propose a new mean-field model of brain rhythms governed by astrocytes. This theoretical framework describes how astrocytes can regulate neuronal activity and contribute to the generation of brain rhythms. The model describes at the population level the interactions between two large groups of excitatory and inhibitory neurons.
arxiv  

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