Results 191 to 200 of about 440,890 (382)
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao+17 more
wiley +1 more source
Quick Access to Human Astrocytic Software that Drives Neuronal Hardware
Astrocytes have important functions in the brain and their deregulation may cause disease. Current ways to derive astrocytes from pluripotent stem cells are labor, time, and resource intensive, but in this issue of Stem Cell Reports, Li et al.
Anders Lundin, Anna Falk
doaj
Astrocytes are the primary cell type in the central nervous system, responsible for maintaining the stability of the brain’s internal environment and supporting neuronal functions.
Jingyu Zhao+10 more
doaj +1 more source
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
L. Sanmarco+17 more
semanticscholar +1 more source
This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao+10 more
wiley +1 more source
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren+11 more
wiley +1 more source
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch+4 more
semanticscholar +1 more source
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang+8 more
wiley +1 more source
Background: Development of synaptic activity is a key neuronal characteristic that relies largely on interactions between neurons and astrocytes. Although astrocytes have known roles in regulating synaptic function and malfunction, the use of human- or ...
Noora Räsänen+11 more
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