Results 201 to 210 of about 461,223 (386)

CSIG-32. RECURRENT ACROCENTRIC TRANSLOCATIONS AND ANAPHASE BRIDGES ARE AN EARLY PHENOTYPE OF PRE-CANCEROUS ASTROCYTES WITH DYSFUNCTIONAL TELOMERES [PDF]

Ogechukwu Mbegbu, Yue Hao, Noelle Fukushima, Ava Bryan, Tianpeng Zhang, Pippa Cosper, Floris Barthel   +6 more
openalex   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Faculty Opinions recommendation of Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow.

, 2020
Scott J. Russo, Laurence Dion‐Albert, Caroline Ménard   +2 more
openalex   +2 more sources

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Nature Neuroscience, 2021
Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, S. Goyon, Daisuke Hagiwara, A. Lefevre, Lara Barteczko, B. Boury-Jamot, Benjamin Bellanger, Marios Abatis, M. D. S. Gouveia, Diego Benusiglio, M. Eliava, Andrej Rozov, Ivan Weinsanto, H. S. Knobloch-Bollmann, Matthew K. Kirchner, Ranjan K. Roy, Hong Wang, M. Pertin, Perrine Inquimbert, C. Pitzer, J. Siemens, Y. Goumon, B. Boutrel, C. Lamy, I. Decosterd, J. Chatton, N. Rouach, Scott Young, J. Stern, P. Poisbeau, R. Stoop, P. Darbon, V. Grinevich, A. Charlet   +36 more
semanticscholar   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Astrocyte-derived exosomes transfer miR-190b to inhibit oxygen and glucose deprivation-induced autophagy and neuronal apoptosis [PDF]

, 2020
Xiaoxi Pei, Yucheng Li, Liangfu Zhu, Zhi-Long Zhou   +3 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Lactate Dehydrogenase Inhibition Reverts the Fatty Acid-Induced Neurotoxic Phenotype of Astrocytes. [PDF]

Glia
Esteve D, Bresque M, Okhuevbie D, Ramachandran S, Pehar M, Vargas MR.   +5 more
europepmc   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source