Results 221 to 230 of about 123,114 (319)

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source

Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus

Journal of Comparative Neurology, Volume 531, Issue 2, Page 281-293, February 2023., 2023
Hippocampal granule cells of adult mice lacking canonical TNF‐Rs were filled with Alexa568 and immunolabeled for Synaptopodin. Morphometric analysis of their spines revealed that TNF‐R mutants partially replicate changes previously reported for TNF‐deficient mice.
Dinko Smilovic, Michael Rietsche, Meike Fellenz, Alexander Drakew, Mario Vuksic, Thomas Deller   +5 more
wiley   +1 more source

A Novel Mixed Convolution Transformer Model for the Fast and Accurate Diagnosis of Glioma Subtypes

Advanced Intelligent Systems, EarlyView.
The mixed convolutional transformer model represents a novel approach for the accurate and rapid diagnosis of glioma subtypes. This model employs advanced, complex layers and functions, establishing its uniqueness and enhancing its ability to deliver precise outcomes in glioma subtype detection.
S. M. Nuruzzaman Nobel, S. M. Masfequier Rahman Swapno, Md Babul Islam, AKM Azad, Salem A. Alyami, Md Alamin, Pietro Liò, Mohammad Ali Moni   +7 more
wiley   +1 more source

Cell morphologies in the nervous system: Glia steal the limelight

Journal of Comparative Neurology, Volume 531, Issue 3, Page 338-343, February 2023., 2023
Diversity of digitally reconstructed glia (astrocytes, oligodendrocytes, microglia, and other types) freely available for download and reuse at NeuroMorpho.Org in terms of experimental provenance, animal species, anatomical region, cell type, tracing platform, and more.
Giorgio A. Ascoli
wiley   +1 more source

Microglial control of astrocytes in response to microbial metabolites

Nature, 2018
V. Rothhammer, Davis M. Borucki, Emily C. Tjon, M. Takenaka, C. Chao, A. Ardura-Fabregat, K. A. de Lima, Cristina Gutiérrez-Vázquez, Patrick Hewson, O. Staszewski, M. Blain, Luke M. Healy, T. Neziraj, Matilde Borio, Michael A. Wheeler, Loic Dragin, D. Laplaud, J. Antel, Jorge I Alvarez, M. Prinz, F. Quintana   +20 more
semanticscholar   +1 more source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Effects of transforming growth factor-beta on murine astrocyte glutamine synthetase activity. Implications in neuronal injury. [PDF]

, 1992
C C Chao, S Hu, Monica Tsang, J A Weatherbee, Thomas W. Molitor, W. R. Anderson, Phillip K. Peterson   +6 more
openalex   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel   +11 more
wiley   +1 more source

Genetically Modified Striatal Astrocytes Grafted to the Brain: Pharmacological Control of an Inducible Promoter [PDF]

, 1992
Edmund F. La Gamma, Gary Weisinger, Nicholas J. Lenn, Robert E. Strecker   +3 more
openalex   +1 more source

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source