Results 61 to 70 of about 249,621 (311)

Expression and modulation of an NADPH oxidase in mammalian astrocytes [PDF]

, 2005
Amyloid β peptides generate oxidative stress in hippocampal astrocytes through a mechanism sensitive to inhibitors of the NADPH oxidase [diphenylene iodonium (DPI) and apocynin].
Abramov, A.Y., Wientjes, F., Duchen, M.R., Jacobson, J., Canevari, L., Hothersall, J.   +5 more
core  

Age-dependent remodelling of ionotropic signalling in cortical astroglia [PDF]

, 2011
Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial.
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Verkhratsky, Alexei, Oleg Palygin, Ulyana Lalo, North, Richard Alan, Richard Alan North, Yuriy Pankratov, North, R. Alan, Verkhratsky, Alexei; id_orcid, Alexei Verkhratsky   +11 more
core   +1 more source

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

Journal of Neuroinflammation, 2020
Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear.
He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu, Xiao-Xia Jiang   +10 more
doaj   +1 more source

Astrocytes and Tinnitus

Brain Sciences
Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based on maladaptive plasticity mechanisms. Astrocytes play a major role in both neural responses to inflammation and plasticity regulation; moreover, they have ...
Paola Perin, Roberto Pizzala
openaire   +4 more sources

Astrocytes Imagined

Journal of Integrative Neuroscience, 2022
The cellular, molecular and physiological basis of cognition has proved elusive until emerging studies on astrocytes. The appearance of a deliberate aggregating element in cellular neurophysiology was difficult to satisfy computationally with excitatory and inhibitory neuron physiology alone.
openaire   +3 more sources

Mechanosensory Signaling in Astrocytes [PDF]

The Journal of Neuroscience, 2020
Mechanosensitivity is a well-known feature of astrocytes, however, its underlying mechanisms and functional significance remain unclear. There is evidence that astrocytes are acutely sensitive to decreases in cerebral perfusion pressure and may function as intracranial baroreceptors, tuned to monitor brain blood flow.
Egor A. Turovsky, Alice Braga, Yichao Yu, Noemi Esteras, Alla Korsak, Shefeeq M. Theparambil, Anna Hadjihambi, Patrick S. Hosford, Anja G. Teschemacher, Nephtali Marina, Mark F. Lythgoe, Philip G. Haydon, Alexander V. Gourine   +12 more
openaire   +5 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes [PDF]

, 2011
Background and purpose Astrocytes of the mouse neocortex express functional NMDA receptors which are not blocked by Mg2+ions. However, study of the pharmacological profile of glial NMDARs and their subunit composition is far from complete ...
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin, Ulyana Lalo, Yuriy Pankratov   +5 more
core   +1 more source

Transcriptional analysis of astrocytes reveals protective functions during remyelination [PDF]

, 2020
In Multiple Sclerosis (MS), the insulating membrane that ensheaths axons termed myelin, is lost by a process known as demyelination. Initial regeneration of myelin, termed remyelination, restores neuronal function.
Molina-González, Irene
core   +1 more source

Brain pericytes upregulate glutamate uptake by astrocytes in vitro through sodium-dependent transporter

IBRO Neuroscience Reports
Astrocytes maintain glutamate homeostasis in the central nervous system (CNS) via glutamate uptake through Na+-dependent excitatory amino acid transporters (EAAT1 and EAAT2), and this process is regulated by several CNS cell types. However, it is unclear
Kenta Sakai, Fuyuko Takata, Takuro Iwao, Miho Yasunaga, Gaku Yamanaka, Yasufumi Kataoka, Shinya Dohgu   +6 more
doaj   +1 more source