Results 61 to 70 of about 380,989 (342)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
New Insights into GFAP Negative Astrocytes in Calbindin D28k Immunoreactive Astrocytes
Brain Sciences, 2018 Glial fibrillary acidic protein (GFAP) is commonly used as a specific marker for the identification of astrocytes. Nevertheless, it is known from the literature that astrocytes in situ in contrast to cultured astrocytes may feature lower levels of GFAP ...
Jie Xu
doaj +1 more source
Direct vascular contact is a hallmark of cerebral astrocytes
Cell Reports, 2022 Summary: Astrocytes establish extensive networks via gap junctions that allow each astrocyte to connect indirectly to the vasculature. However, the proportion of astrocytes directly associated with blood vessels is unknown.
Ladina Hösli +6 more
doaj +1 more source
From astrocyte destruction to axon injury: watching lesion evolution in experimental neuromyelitis optica [PDF]
, 2022 Monika Bradl
openalex +1 more source
Exploring the Production of Extracellular Matrix by Astrocytes in Response to Mimetic Traumatic Brain Injury [PDF]
, 2016 Following injury to the central nervous system, extracellular modulations are apparent at the site of injury, often resulting in a glial scar. Astrocytes are mechanosensitive cells, which can create a neuroinhibitory extracellular environment in response
Walker, Addison
core +2 more sources
Connexin-dependent neuroglial networking as a new therapeutic target [PDF]
, 2017 Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks.
Christian C. Naus +5 more
core +2 more sources
Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes. [PDF]
, 2020 Zika virus (ZIKV) infection in the human central nervous system (CNS) causes Guillain-Barre syndrome, cerebellum deformity, and other diseases. Astrocytes are immune response cells in the CNS and an important component of the blood-brain barrier ...
Hu, Q +12 more
core +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]
, 2015 Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
core +1 more source