Results 51 to 60 of about 249,621 (311)

Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides

Frontiers in Psychiatry, 2021
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide.
Liam Anuj O'Leary, Liam Anuj O'Leary, Claudia Belliveau, Claudia Belliveau, Maria Antonietta Davoli, Jie Christopher Ma, Arnaud Tanti, Gustavo Turecki, Gustavo Turecki, Gustavo Turecki, Naguib Mechawar, Naguib Mechawar, Naguib Mechawar   +12 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. [PDF]

, 2009
Blood-brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the neurovascular unit.
Tanaka, Kunihiko, Deli, Maria A., Deli, Mária A, Kittel, Agnes, Nakagawa, Shinsuke, Shimono, Takanori, Kawaguchi, Hiroko, Niwa, Masami, Shimizudani, Takeshi   +8 more
core   +1 more source

Hydrogen Peroxide-Induced Thymidine Incorporation Into Cultured Rat Astrocytes

Journal of Pharmacological Sciences, 2006
We characterized [methyl-3H]thymidine ([3H]thymidine) and [5-3H]uridine ([3H]uridine) incorporation into cultured astrocytes and neurons in the presence and absence of hydrogen peroxide (H2O2) in order to define the response to oxidative stress in the ...
Koh-ichi Tanaka, Tomoaki Sato, Yoshiko Ohnishi, Takashige Nishikawa   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

properties of spinal astrocytes [PDF]

, 2021
Astrocytes are indispensable for proper neuronal functioning. Given the diverse needs of neuronal circuits and the variety of tasks astrocytes perform, the perceived homogeneous nature of astrocytes has been questioned. In the spinal dorsal horn, complex
Sandkühler, Jürgen, Mira T. Kronschläger, Rajendran, Pradeep S., Khakh, Baljit S., Jürgen Sandkühler, Felix J. Resch, Siegert, Anna S.M., Baljit S. Khakh, Anna S. M. Siegert, Pradeep S. Rajendran, Kronschläger, Mira T., Resch, Felix J.   +11 more
core   +1 more source

Astrocytes: Structure, functions and role in disease [PDF]

, 2012
Astrocytes are the main glial cell type in the central nervous system. These cells were originally regarded as supportive cells of the brain, but increasing evidence indicates they play fundamental roles in many brain functions, such as ...
Gonzalez-Perez, O.
core   +2 more sources

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons

Frontiers in Cell and Developmental Biology, 2023
Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD ...
Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Martin Montecino, Brigitte van Zundert, Brigitte van Zundert   +19 more
doaj   +1 more source

Astrocytes in Flavivirus Infections [PDF]

International Journal of Molecular Sciences, 2019
Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by ...
Maja Potokar, Jernej Jorgačevski, Robert Zorec   +2 more
openaire   +3 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source