Results 41 to 50 of about 249,621 (311)
Astrocytes in CNS Disorders [PDF]
Over the past 30 years, astrocytes have emerged from a supporting role to co-starring with neurons and oligodendrocytes as players in CNS disorders. Dysfunction of astrocytes is now implicated in disorders once thought to be solely of neuronal origin ...
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NeuronThe mammalian nervous system is impacted by aging. Aging alters brain architecture, is associated with molecular damage, and can manifest with cognitive and motor deficits that diminish the quality of life. Astrocytes are glial cells of the CNS that regulate the development, function, and repair of neural circuits during development and adulthood ...
Lara Labarta-Bajo, Nicola J. Allen
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Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes [PDF]
, 2023 Astragaloside IV (AST IV), a major saponin component and active ingredient isolated from Astragalus membranaceus, has been well known to exhibit neuroprotective effects on diverse models of neurological diseases.
Yuqing Yan +9 more
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Cells, 2022 Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mouse ...
Markus Leo +6 more
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Journal of Pharmacological Sciences, 2020 The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi +3 more
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Astrocytes, emerging stars of energy homeostasis [PDF]
, 2018 Astrocytes have historically been considered structural supporting cells for neurons. Thanks to new molecular tools, allowing specific cell ablation or over-expression of genes, new unexpected astrocytic functions have recently been unveiled. This review
Simonetta Camandola
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Pathology and Astrocytes in Autism [PDF]
, 2023 Gelareh Vakilzadeh,1,2 Veronica Martinez-Cerdeño1– 3 1Department of Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA, USA; 2Institute for Pediatric Regenerative Medicine, and Shriners Hospitals for Children, Sacramento, CA ...
Martinez-Cerdeño V, Vakilzadeh G
core
Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytes.
PLoS ONE, 2014 Astrocytes protect neurons, but also evoke proinflammatory responses to injury and viral infections, including HIV. There is a prevailing notion that HIV-1 Rev protein function in astrocytes is perturbed, leading to restricted viral replication.
Ashok Chauhan
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Journal of Neuroinflammation, 2023 Background Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD).
Evangelos Konstantinidis +5 more
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