Results 21 to 30 of about 273,908 (305)

Astrocytes in schizophrenia [PDF]

Brain and Neuroscience Advances, 2021
Schizophrenia is a severe and clinically heterogenous mental disorder affecting approximately 1% of the population worldwide. Despite tremendous achievements in the field of schizophrenia research, its precise aetiology remains elusive. Besides dysfunctional neuronal signalling, the pathophysiology of schizophrenia appears to involve molecular and ...
openaire   +2 more sources

Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development

Frontiers in Neuroscience, 2020
Astrocytes exhibit a region-dependent molecular and functional heterogeneity in the CNS. Although cortical astrocytes proliferate robustly during the first postnatal week and become proliferation quiescent, the temporal proliferation dynamics of ...
Temitope Shoneye, Alessandra Tamashiro Orrego, Rachel Jarvis, Yuqin Men, Ming Sum R. Chiang, Yongjie Yang, Yongjie Yang   +6 more
doaj   +1 more source

Characterization of Vimentin-Immunoreactive Astrocytes in the Human Brain

Frontiers in Neuroanatomy, 2020
Astrocytes are commonly identified by their expression of the intermediate filament protein glial fibrillary acidic protein (GFAP). GFAP-immunoreactive (GFAP-IR) astrocytes exhibit regional heterogeneity in density and morphology in the mouse brain as ...
Liam Anuj O’Leary, Liam Anuj O’Leary, Maria Antonietta Davoli, Claudia Belliveau, Claudia Belliveau, Arnaud Tanti, Jie Christopher Ma, William Todd Farmer, Gustavo Turecki, Gustavo Turecki, Gustavo Turecki, Keith Kazuo Murai, Naguib Mechawar, Naguib Mechawar, Naguib Mechawar   +14 more
doaj   +1 more source

Activation of a neural stem cell transcriptional program in parenchymal astrocytes

eLife, 2020
Adult neural stem cells, located in discrete brain regions, generate new neurons throughout life. These stem cells are specialized astrocytes, but astrocytes in other brain regions do not generate neurons under physiological conditions.
Jens P Magnusson, Margherita Zamboni, Giuseppe Santopolo, Jeff E Mold, Mauricio Barrientos-Somarribas, Carlos Talavera-Lopez, Björn Andersson, Jonas Frisén   +7 more
doaj   +1 more source

TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer’s diseases

Redox Biology, 2023
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of Alzheimer’s disease (AD). Neuroinflammation and oxidative stress are associated with neuronal death in AD. Astrocytes are linked to neuroinflammation during AD. Astrocytes
Junhyung Kim, Jaejoon Lim, Ik Dong Yoo, Samel Park, Jong-Seok Moon   +4 more
doaj   +1 more source

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Cell Communication and Signaling, 2023
Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen   +10 more
doaj   +1 more source

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad, Pankratov Yuriy, Lalo Ulyana, Andrew Jemma, Palygin Oleg, Rasooli-Nejad Seyed, Haydon Philip G.   +23 more
core   +2 more sources

Astrocytes in Tauopathies [PDF]

Frontiers in Neurology, 2020
Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and localization.
Reid, Matt, Beltran Lobo, Paula, Johnson, Louisa, Gomez Perez-Nievas, Bea, Noble, Wendy   +4 more
openaire   +4 more sources

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Lalo, Ulyana, Pankratov, Yuriy, Verkhratsky, A. N. (Alekseĭ Nestorovich), Wichert, S., Kirchhoff, F., Rossner, Moritz J., Verkhratsky, Alexei; id_orcid, Kirchhoff, Frank, Verkhratsky, Alexei, Pankratov, Y., Rossner, M., Lalo, U., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), North, R., Pankratov, Yuri, North, R. Alan, Verkhratsky, A., Wichert, Sven P.   +17 more
core   +1 more source

The astrocyte odyssey [PDF]

Progress in Neurobiology, 2008
Neurons have long held the spotlight as the central players of the nervous system, but we must remember that we have equal numbers of astrocytes and neurons in the brain. Are these cells only filling up the space and passively nurturing the neurons, or do they also contribute to information transfer and processing?
Doris D, Wang, Angélique, Bordey
openaire   +2 more sources