Results 121 to 130 of about 75,763 (246)

Prospective inter‐individual analysis of quality‐adjusted life years (QALYs) in brain tumor patients: A comprehensive assessment of health preferences

International Journal of Cancer, Volume 158, Issue 5, Page 1250-1261, 1 March 2026.
What's New? Eloquent intracranial tumors present unique challenges in neurosurgical treatment due to their proximity to critical functional areas of the brain. This prospective, single‐center cohort study quantified real‐time changes in patients' subjective burden of health impairments using the Time Trade‐Off and Standard Gamble methods, providing ...
Lisa S. Hönikl, Anna Kelm, Sandro M. Krieg, Bernhard Meyer, Vicki M. Butenschoen   +4 more
wiley   +1 more source

Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis

Journal of Neuropathology and Experimental Neurology, 2018
M. Hasselblatt, Mohammed Jaber, D. Reuss, O. Grauer, Annkatrin Bibo, Stephanie Terwey, U. Schick, Heinrich Ebel, T. Niederstadt, W. Stummer, A. von Deimling, W. Paulus   +11 more
semanticscholar   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Impact of prenatal sirolimus on cardiac rhabdomyomas and brain tubers

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 350-359, March 2026.
ABSTRACT Objective To document the natural progression of fetal cardiac rhabdomyomas and evaluate the impact of prenatal sirolimus (PNS) on tumor size, cardiac complications and brain‐tuber size. Methods This was a single‐center retrospective cohort study of pregnancies with suspected fetal cardiac rhabdomyoma referred to our center from April 2013 to ...
S. Vergote, L. Van der Veeken, D. Chitayat, E. Jaeggi, G. Ryan, E. Miller, S. Shinar   +6 more
wiley   +1 more source

Methylmalonic Acid, an Aging‐Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2‐STAT3/VEGF Signaling Axis

Aging Cell, Volume 25, Issue 3, March 2026.
Our study reveals that elevated MMA in aged intervertebral discs promotes degeneration by activating the CCL7/JAK2‐STAT3/VEGF signaling axis, which drives pathological vascularization. Therapeutically, the VEGFR inhibitor lenvatinib attenuated this process, identifying disc vascularization as a promising therapeutic target for IVDD.
Yuanzhang Jin, Runtian Zhou, Xiaonan Wang, Haifeng Liu, Xiaofeng Zhao, Doudou Jing, Bin Zhao   +6 more
wiley   +1 more source

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.

The Lancet Oncology, 2012
W. Wick, M. Plattén, C. Meisner, J. Felsberg, G. Tabatabai, M. Simon, G. Nikkhah, K. Papsdorf, J. Steinbach, M. Sabel, S. Combs, J. Vesper, Christian Braun, J. Meixensberger, R. Ketter, R. Mayer‐Steinacker, G. Reifenberger, M. Weller   +17 more
semanticscholar   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for WHO CNS5 adult‐type diffuse gliomas

Brain Pathology, Volume 36, Issue 2, March 2026.
ADAPTR recommendations for Adult‐type Diffuse Gliomas in Resource‐restrained settings. Abstract The fifth edition of the WHO classification of CNS Tumors (WHO CNS5) has revised the diagnostic and grading criteria for Adult‐type Diffuse Gliomas (ADGs) by integrating molecular parameters with histologic features.
Vani Santosh, Chitra Sarkar, Shilpa Rao, Ho‐Keung Ng, Junji Shibahara, Maysa Al‐Hussaini, Michael E. Buckland, Sung‐Hye Park, Tarik Tihan, Pieter Wesseling, David N. Louis, Takashi Komori   +11 more
wiley   +1 more source

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

Nature Genetics, 2013
David T. W. Jones, B. Hutter, N. Jäger, A. Korshunov, M. Kool, H. Warnatz, T. Zichner, S. Lambert, M. Ryzhova, Dong Anh Khuong Quang, A. Fontebasso, A. Stütz, S. Hutter, Marc Zuckermann, D. Sturm, J. Gronych, Bärbel Lasitschka, Sabine Schmidt, H. Şeker-Cin, H. Witt, M. Sultan, M. Ralser, P. Northcott, V. Hovestadt, S. Bender, E. Pfaff, S. Stark, D. Faury, J. Schwartzentruber, J. Majewski, Ursula D. Weber, M. Zapatka, Benjamin Raeder, M. Schlesner, Catherine L. Worth, C. Bartholomae, C. von Kalle, Charles D. Imbusch, S. Radomski, C. Lawerenz, P. V. van Sluis, J. Koster, R. Volckmann, R. Versteeg, H. Lehrach, C. Monoranu, B. Winkler, A. Unterberg, C. Herold‐Mende, T. Milde, A. Kulozik, M. Ebinger, M. Schuhmann, Yoon-Jae Cho, S. Pomeroy, A. von Deimling, O. Witt, Michael D. Taylor, S. Wolf, M. Karajannis, C. Eberhart, W. Scheurlen, M. Hasselblatt, K. Ligon, M. Kieran, J. Korbel, M. Yaspo, B. Brors, J. Felsberg, G. Reifenberger, V. Collins, N. Jabado, R. Eils, P. Lichter, S. Pfister   +74 more
semanticscholar   +1 more source

Meflin/ISLR is a meningeal cell‐specific marker involved in the development of meninges and meningioma progression

Brain Pathology, Volume 36, Issue 2, March 2026.
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki, Tomotsugu Kurauchi, Akitoshi Hara, Nobutoshi Esaki, Shinji Mii, Ryota Ando, Akihiro Sakai, Kuniaki Tanahashi, Fumiharu Ohka, Ryuta Saito, Atsushi Natsume, Yuki Hattori, Takaki Miyata, Atsushi Enomoto   +13 more
wiley   +1 more source

Astrocytoma

, 2021
Jahangir Moini, Nicholas G. Avgeropoulos, Mohtashem Samsam   +2 more
  +4 more sources