Results 11 to 20 of about 57,588 (263)

Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence

npj Precision Oncology, 2023
Astrocytoma and glioblastoma (GB) are reclassified subtypes of adult diffuse gliomas based on distinct isocitrate dehydrogenase (IDH) mutation in the fifth edition of the WHO Classification of Tumors of the Central Nervous System.
Jinsen Zhang, Yuan Feng, Guanghao Li, Jianhua Zhang, Xin Zhang, Yi Zhang, Zhiyong Qin, Dongxiao Zhuang, Tianming Qiu, Zhifeng Shi, Wei Zhu, Rui Zhang, Yonghe Wu, Haikun Liu, Dandan Cao, Wei Hua, Ying Mao   +16 more
doaj   +2 more sources

Mislocalization of the exitatory amino-acid transporters (EAATs) in human astrocytoma and non-astrocytoma cancer cells: effect of the cell confluence [PDF]

Journal of Biomedical Science, 2012
Background Astrocytomas are cancers of the brain in which high levels of extracellular glutamate plays a critical role in tumor growth and resistance to conventional treatments.
Varini Karine, Benzaria Amal, Taïeb Nadira, Di Scala Coralie, Azmi Amanda, Graoudi Soraya, Maresca Marc   +6 more
doaj   +2 more sources

Astrocytoma [PDF]

JKS (Jurnal Kedokteran Syiah Kuala), 2009
Abstnk.   Astrocytoma  merupakan  tumor otak yang  paling sering terjadi  pada anak, dengan frekuensi lebih dari setengah jumlah  keganasan pada sistem saraf primer.  Insidensi   tahunan  mencapai 14 kasus baru per 1000000 anak dibawah   usia 15   tahun.
Fahrul Amri
doaj   +1 more source

Pilocytic Astrocytoma Presenting as an Orbital Encephalocele: A Case Report

Case Reports in Neurology, 2015
We describe the case of a 29-year-old male who presented with new-onset seizures. He was subsequently found to have an orbital encephalocele containing a focus of pilocytic astrocytoma.
Amy Bruzek, Daniel Shepherd, Jamie Van Gompel, Mark Jentoft   +3 more
doaj   +2 more sources

Clinical Impact of MGMT Promoter Methylation in IDH-Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding. [PDF]

Ann Clin Transl Neurol
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Jiang H, Cao L, Chen X, Tong S, Zhu Q, Yang J, Lin S, Cui Y.   +7 more
europepmc   +2 more sources

Novel insight into histological and molecular astrocytoma, IDH‐mutant, Grade 4 by the updated WHO classification of central nervous system tumors

Cancer Medicine, 2023
Background The latest fifth edition of the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (WHO CNS 5 classification) released in 2021 defined astrocytoma, IDH‐mutant, Grade 4.
Wenlin Chen, Siying Guo, Yaning Wang, Yixin Shi, Xiaopeng Guo, Delin Liu, Yilin Li, Yuekun Wang, Hao Xing, Yu Xia, Junlin Li, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Huanzhang Li, Tianrui Yang, Kun Zhang, Yu Wang, Wenbin Ma   +21 more
doaj   +1 more source

Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma

Acta Neuropathologica Communications, 2023
In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive.
Kensuke Tateishi, Yohei Miyake, Taishi Nakamura, Hiromichi Iwashita, Takahiro Hayashi, Akito Oshima, Hirokuni Honma, Hiroaki Hayashi, Kyoka Sugino, Miyui Kato, Kaishi Satomi, Satoshi Fujii, Takashi Komori, Tetsuya Yamamoto, Daniel P. Cahill, Hiroaki Wakimoto   +15 more
doaj   +1 more source

Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma [PDF]

Neurospine, 2023
Objective Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported.
Lei Cheng, Wanru Duan, Jian Guan, Kai Wang, Zhenlei Liu, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian   +9 more
doaj   +1 more source

Antigen p57/Kip2 as a potential negative regulator of human astrocytoma growth [PDF]

, 2009
This study was performed to determine the relationship between p57/Kip2 and the growth of human astrocytomas. Immunohistochemical staining for p57/Kip2, p53, p16, and Ki67 antigen was performed on paraffin-embedded tissue specimens obtained from 36 ...
Akaishi, Kotaro, Rutka, James T, Nakayama, Jun, Sakai, Keiichi, Kobayashi, Tatsuya   +4 more
core   +1 more source

Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway

Journal of Experimental & Clinical Cancer Research, 2017
Background The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar and spindle associated protein 1 (NUSAP1) was observed in several types of cancers, but its role in ...
Xianqiu Wu, Benke Xu, Chao Yang, Wentao Wang, Dequan Zhong, Zhan Zhao, Longshuang He, Yuanjun Hu, Lili Jiang, Jun Li, Libing Song, Wei Zhang   +11 more
doaj   +1 more source