Results 21 to 30 of about 46,157 (226)

Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma

Acta Neuropathologica Communications, 2023
In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive.
Kensuke Tateishi, Yohei Miyake, Taishi Nakamura, Hiromichi Iwashita, Takahiro Hayashi, Akito Oshima, Hirokuni Honma, Hiroaki Hayashi, Kyoka Sugino, Miyui Kato, Kaishi Satomi, Satoshi Fujii, Takashi Komori, Tetsuya Yamamoto, Daniel P. Cahill, Hiroaki Wakimoto   +15 more
doaj   +1 more source

SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis

BMC Cancer, 2020
Background Astrocytoma is a common tumor type in primary central nervous system and has a high death rate around the world. Aberrant expression of long non-coding RNAs (lncRNAs) has been introduced by emerging studies to result in the development of ...
Fengping Du, Qian Hou
doaj   +1 more source

Expression of delta-catenin is associated with progression of human astrocytoma

BMC Cancer, 2011
Background δ-Catenin (CTNND2), which encodes a scaffold protein in humans, has been found in a few malignancies. However, the expression pattern and contribution of δ-catenin to astrocytoma progression are unclear.
MingHao Wang, Qianze Dong, Di Zhang, YunJie Wang   +3 more
doaj   +1 more source

Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence

npj Precision Oncology, 2023
Astrocytoma and glioblastoma (GB) are reclassified subtypes of adult diffuse gliomas based on distinct isocitrate dehydrogenase (IDH) mutation in the fifth edition of the WHO Classification of Tumors of the Central Nervous System.
Jinsen Zhang, Yuan Feng, Guanghao Li, Jianhua Zhang, Xin Zhang, Yi Zhang, Zhiyong Qin, Dongxiao Zhuang, Tianming Qiu, Zhifeng Shi, Wei Zhu, Rui Zhang, Yonghe Wu, Haikun Liu, Dandan Cao, Wei Hua, Ying Mao   +16 more
doaj   +1 more source

Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma [PDF]

Neurospine, 2023
Objective Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported.
Lei Cheng, Wanru Duan, Jian Guan, Kai Wang, Zhenlei Liu, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian   +9 more
doaj   +1 more source

Unraveling the signaling mechanism behind astrocytoma and possible therapeutics strategies: A comprehensive review

Cancer Reports, 2023
Background A form of cancer called astrocytoma can develop in the brain or spinal cord and sometimes causes death. A detailed overview of the precise signaling cascade underlying astrocytoma formation has not yet been revealed, although various factors ...
Chowdhury Lutfun Nahar Metu, Sunita Kumari Sutihar, Md Sohel, Fatematuz Zohora, Akayed Hasan, Md. Thandu Miah, Tanu Rani Kar, Md. Arju Hossain, Md Habibur Rahman   +8 more
doaj   +1 more source

Mislocalization of the exitatory amino-acid transporters (EAATs) in human astrocytoma and non-astrocytoma cancer cells: effect of the cell confluence

Journal of Biomedical Science, 2012
Background Astrocytomas are cancers of the brain in which high levels of extracellular glutamate plays a critical role in tumor growth and resistance to conventional treatments.
Varini Karine, Benzaria Amal, Taïeb Nadira, Di Scala Coralie, Azmi Amanda, Graoudi Soraya, Maresca Marc   +6 more
doaj   +1 more source

Transcriptome analysis reveals distinct gene expression profiles in astrocytoma grades II-IV

Biomedical Papers, 2017
Background: Astrocytoma is the most prevalent form of primary brain cancer categorized into four histological grades by the World Health Organization. Investigation into individual grades of astrocytoma by previous studies has provided some insight into ...
Nato Narsia, Pradeep Ramagiri, Jiri Ehrmann, Zdenek Kolar   +3 more
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Risk factor analysis and nomogram establishment and verification of brain astrocytoma patients based on SEER database

Scientific Reports, 2023
Astrocytoma is a common brain tumor that can occur in any part of the central nervous system. This tumor is extremely harmful to patients, and there are no clear studies on the risk factors for astrocytoma of the brain.
Ruiqi Wang, Jiaxue Cui, Yizhuo Diao, Chenxin Jin, Yongxing Chen, Xiupeng Lv, Xiaofeng Li   +6 more
doaj   +1 more source

A rare, pediatric, fourth-ventricular, anaplastic astrocytoma

Radiology Case Reports, 2021
Anaplastic astrocytoma, a diffusely infiltrating, malignant, astrocytic, primary brain tumor, is most commonly observed between 30 and 50 years of age. Anaplastic astrocytomas are now classified as WHO grade III lesions, with imaging characteristics and ...
Dang Vinh Hiep, MD, PhD, Nguyen Minh Duc, MD, MSc, Nguyen Quoc Dung, MD, PhD   +2 more
doaj   +1 more source