Results 51 to 60 of about 109,064 (360)

SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B

Journal of Hematology & Oncology, 2017
BackgroundSIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our previous study showed that the SIX3 gene is hypermethylated, and its expression is decreased
Zhibin Yu, Yingnan Sun, X. She, Zeyou Wang, Shuai Chen, Zhiyong Deng, Yan Zhang, Qiang Liu, Qing Liu, Chunhua Zhao, Peiyao Li, Changhong Liu, Jianbo Feng, Haijuan Fu, Guiyuan Li, Minghua Wu   +15 more
semanticscholar   +1 more source

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. [PDF]

, 2016
Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients ...
Berger, Mitchel S, Daynac, Mathieu, Grossauer, Stefan, James, C David, Koeck, Katharina, McMahon, Martin, Meyers, Ian D, Murphy, Nicole E, Nicolaides, Theodore P, Petritsch, Claudia K, Phillips, Joanna J, Truffaux, Nathalene, Truong, Albert Y   +12 more
core   +1 more source

In silico analysis identifies a putative cell-of-origin for BRAF fusion-positive cerebellar pilocytic astrocytoma

PLoS ONE, 2020
Childhood cancers are increasingly recognized as disorders of cellular development. This study sought to identify the cellular and developmental origins of cerebellar pilocytic astrocytoma, the most common brain tumor of childhood.
Subhi Talal Younes, Betty Herrington, Marta M. Alonso   +2 more
doaj   +2 more sources

Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]

, 2011
G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core   +3 more sources

Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis.

Neuro-Oncology Practice, 2016
Background The survival trends and the patterns of clinical practice pertaining to radiation therapy and surgical resection for WHO grade I, II, and III astrocytoma patients remain poorly characterized.
Xuezhi Dong, A. Noorbakhsh, B. Hirshman, Tianzan Zhou, Jessica A. Tang, D. Chang, B. Carter, Clark C. Chen   +7 more
semanticscholar   +1 more source

Child-related characteristics predicting subsequent health-related quality of life in 8- to 14-year-old children with and without cerebellar tumors: a prospective longitudinal study

, 2014
BackgroundWe identified child-related determinants of health-related quality of life (HRQoL) in children aged 8–14 years who were treated for 2 common types of pediatric brain tumors.
Armstrong, Aukema, Barrera, Bhat, Boman, Boman, Boruk, Bull, Butler, Cantelmi, Chang, Cramm, Dorner, Embry, Engelen, Feeny, Fuemmeler, Gioia, Goldberg, Goodman, Gudrunardottir, Hardy, Jokovic, Karlson, Kennedy, Korinthenberg, Kroll, Krull, Kuhlthau, Lancashire, Lannering, LeBaron, Limond, Lucey, Msall, Musial-Bright, Nejat, Odame, Ogiwara, Olson, Packer, Palmer, Reimers, Ribi, Roncadin, Stewart, Varni, Varni, Varni, Varni, Varni, Wechsler, Zuzak   +52 more
core   +1 more source

Impact of Human Immunodeficiency Virus in the Pathogenesis and Outcome of Patients with Glioblastoma Multiforme. [PDF]

, 2016
BackgroundImprovement in antiviral therapies have been accompanied by an increased frequency of non-Acquired Immune Deficiency Syndrome (AIDS) defining malignancies, such as glioblastoma multiforme.
Bui, Timothy T, Choy, Winward, Lagman, Carlito, Lee, Seung J, Safaee, Michael, Yang, Isaac   +5 more
core   +1 more source

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction [PDF]

, 2004
Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Dingwall, C, Everett, DM, Murdock, PR, Owen, JS, Thilakawardhana, S   +4 more
core   +1 more source

Evaluation of miR-362 Expression in Astrocytoma of Human Brain Tumors

Advanced Biomedical Research, 2017
Background: Patients affected by gliomas have a poor prognosis. Astrocytoma is a subtype of glioma. Identification of biomarkers could be an effective way to an early diagnosis of tumor or to distinguish more aggressive tumors that need more intensive ...
Majid Kheirollahi, Mahdiye Moodi, Saeideh Ashouri, Parvaneh Nikpour, Mohammad Kazemi   +4 more
doaj   +1 more source

Perinatal (fetal and neonatal) astrocytoma: a review

Child's Nervous System, 2016
IntroductionThe purpose of this review is to document the various types of astrocytoma that occur in the fetus and neonate, their locations, initial findings, pathology, and outcome.
H. Isaacs
semanticscholar   +1 more source