Results 61 to 70 of about 2,602 (175)
Cell Type‐Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.The formation of long‐term memories depends on de novo protein synthesis, a process tightly regulated by the mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. mTORC1 plays a central role in promoting mRNA translation in the central nervous system.
Ziying Huang +5 more
wiley +1 more source
Advances in targeted degradation of endogenous proteins [PDF]
, 2019 Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been developed, including targeting the encoding genes ...
Fulcher, Luke +2 more
core +2 more sources
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, Volume 5, Issue 9, September 2025.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Журнал инфектологии, 2018 The aim of the study was to evaluate clinical, immunologic and anti-viral efficacy of antiviral therapy (АVT) with drugs of the direct antiviral action (DAA) of the chronic hepatitis C (CHC) complicated with secondary mixed cryoglobulinemia in small ...
N. V. Dunaeva +5 more
doaj +1 more source
Pharmaceuticals, 2022 The inhibition of P-glycoprotein (ABCB1) could lead to increased drug plasma concentrations and hence increase drug toxicity. The evaluation of a drug’s ability to inhibit ABCB1 is complicated by the presence of several transport-competent sites within ...
Martin Huličiak +5 more
doaj +1 more source
, 2014 AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and ...
Amanzada, Ahmad +3 more
core +1 more source
Reassessment of genotype 1 hepatitis c virus subtype misclassification by LiPA 2.0: implications for direct-acting antiviral treatment [PDF]
, 2014 The accuracy of LiPA 2.0 for hepatitis C virus 1 (HCV-1) subtype classification was analyzed. LiPA 2.0 genotype results from 101 HCV-1-infected patients were compared to genotype findings determined by direct core sequencing.
Di Lello, Federico Alejandro +9 more
core +1 more source
Alimentary Pharmacology &Therapeutics, Volume 62, Issue 2, Page 146-158, July 2025.HCV clearance during direct‐acting antiviral therapy rapidly increases serum lipids and lipoproteins, potentially elevating cardiovascular risk. These metabolic changes, mediated by genes regulating hepatic lipogenesis, suggest that lipid levels should be closely monitored post‐SVR to assess long‐term cardiovascular implications.
Zahra Sarrafan‐Chaharsoughi +12 more
wiley +1 more source
Asunaprevir, a protease inhibitor for the treatment of hepatitis C infection
Therapeutics and Clinical Risk Management, 2014 Ivan Gentile,1 Antonio Riccardo Buonomo,1 Emanuela Zappulo,1 Giuseppina Minei,1 Filomena Morisco,2 Francesco Borrelli,1 Nicola Coppola,3 Guglielmo Borgia1 1Section of Infectious Diseases, 2Section of Gastroenterology, Department of Clinical Medicine and ...
Gentile I +7 more
doaj
Strategies for Biomethane Purification: A Critical Review and New Approaches
GCB Bioenergy, Volume 17, Issue 5, May 2025.ABSTRACT The global shift towards clean energy emphasizes waste valorization as a key to achieving sustainable development goals. Biomethane production from organic waste not only converts waste to energy but also reduces greenhouse gas emissions. The growth trajectory of sustainability and environmental protection highlights the significance of energy
Lolo Errol Molatudi +2 more
wiley +1 more source