Results 71 to 80 of about 1,816 (169)

Small‐Molecule Regulators for Gene Switches to Program Mammalian Cell Behaviour

ChemBioChem, Volume 25, Issue 6, March 15, 2024.
Small molecules have been widely utilized within the synthetic biology community as trigger input for regulating implemented genetic circuit in engineered mammalian cells. Here, we described the most commonly used small molecules and their associated genetic switches, employed to program cell behaviors, particularly within a cell and gene therapy ...
Maysam Mansouri, Martin Fussenegger
wiley   +1 more source

The scatter plots between serum concentrations of asunaprevir and either Mac-2 binding protein glycosylation isomer (M2BPGi) Levels, FIB4 index, serum albumin levels and peripheral platelet counts.

, 2018
Serum asunaprevir concentrations were positively correlated with serum M2BPGi levels (r = 0.418 ...
Kayoko Sugawara (5848991), Yukinori Imai (5849006), Nobuaki Nakayama (5849003), Masamitsu Nakao (5848994), Mie Inao (5849000), Satoshi Mochida (156566), Jun-ichi Kouyama (661243), Daisuke Motoya (5848997), Yoshihito Uchida (661242), Kayoko Naiki (661244), Tomoaki Tomiya (479370)   +10 more
core   +1 more source

Reaction Space Charting as a Tool in Organic Chemistry Research and Development

Advanced Synthesis &Catalysis, Volume 366, Issue 4, Page 551-573, February 20, 2024.
Abstract The chemical and reaction spaces are incredibly vast and special procedures are required to study them. Their complex and multiparametric nature encompass myriads of compounds and interactions and endless modifications involving the distinct impact of relevant variables (temperature, solvent, stoichiometry, etc.).
Eloy Lozano Baró, Pau Nadal Rodríguez, Jordi Juárez‐Jiménez, Ouldouz Ghashghaei, Rodolfo Lavilla   +4 more
wiley   +1 more source

Direct anti-HCV agents

Acta Pharmaceutica Sinica B, 2016
Unlike human immunodeficiency virus (HIV) and hepatitis B virus (HBV), hepatitis C virus (HCV) infection is a curable disease. Current direct antiviral agent (DAA) targets are focused on HCV NS3/4A protein (protease), NS5B protein (polymerase) and NS5A ...
Xingquan Zhang
doaj   +1 more source

Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis

, 2015
IMPORTANCE: Effective and well-tolerated, interferon-free regimens are needed for treatment of patients with chronic hepatitis C virus (HCV) infection and cirrhosis. OBJECTIVE: All-oral therapy with daclatasvir (nonstructural protein 5A [NS5A] inhibitor),
Everson, G, Muir, Andrew J., McPhee, Fiona, Poordad, Fred, Dore, Gregory J, Yin, Philip D., Ramji, A, Yang, R, Ghesquiere, W, Pockros, Paul J, Hughes, Eric A., Reau, N, Thompson, AJ, Pockros, Paul J., Swenson, E. Scott, Pockros, PJ, Kwo, P, Ghesquiere, Wayne, Vierling, J, Tran, Albert, Reau, Nancy, Muir, Andrew J, Yang, Rong, Everson, Gregory, Tran, A, Lalezari, Jacob, Thompson, Alexander J, Herring, R, Lalezari, J, Hézode, Christophe, Vierling, John, Yozviak, J, Ramji, Alnoor, Yozviak, Joseph, Freilich, B, Sheikh, A, Cooper, James, Hézode, C, Stuart, K, Poordad, F, Hughes, EA, Dore, Gregory J., Swenson, ES, Swenson, E Scott, Freilich, Bradley, Yin, Philip D, Sheikh, Aasim, Muir, AJ, Kwo, Paul, Yozviak, Joseph L, DO, FACP, Hughes, Eric A, McPhee, F, Thompson, Alexander J., Dore, GJ ; https://orcid.org/, Herring, Robert, Stuart, Katherine, Yin, PD, Cooper, J   +57 more
core   +1 more source

Efficacy and safety of daclatasvir and asunaprevir combination therapy in chronic hemodialysis patients with chronic hepatitis C [PDF]

, 2016
Background: HCV infection in chronic hemodialysis patients is high, has a poor prognosis and high risk of renal graft failure, and requires nosocomial infection control measures.
Konno, Jun, Izumi, Takaaki, Terashita, Katsumi, Natsuizaka, Mitsuteru, Kimura, Megumi, Tateyama, Miki, Yamamoto, Yoshiya, Shinada, Keisuke, Sakamoto, Naoya, Sato, Fumiyuki, Morikawa, Kenichi, Sho, Takuya, Umemura, Machiko, Nagasaka, Atsushi, Tsukuda, Yoko, Nakai, Masato, Furuya, Ken, Kudo, Mineo, Kobayashi, Tomoe, Suda, Goki, Ogawa, Koji, Tsunematsu, Seiji, Yamasaki, Kazushi, Horimoto, Hiromasa   +23 more
core   +1 more source

Efficacy of an Interferon- and Ribavirin-Free Regimen of Daclatasvir, Asunaprevir, and BMS-791325 in Treatment-Naive Patients With HCV Genotype 1 Infection

, 2014
Background & AimsThe combination of peginterferon and ribavirin with telaprevir or boceprevir is the standard treatment of hepatitis C virus (HCV) genotype 1 infection.
Grasela, Dennis M., Tatum, Harvey, Sims, Karen D., McPhee, Fiona, Wang, Xiaodong, Hézode, Christophe, Loustaud-Ratti, Veronique, Pol, Stanislas, Marcellin, Patrick, Schwartz, Howard, Chung, Ellen, Pasquinelli, Claudio, Eley, Timothy, Huang, Shu-Pang, Rodriguez-Torres, Maribel, Thuluvath, Paul J., Wind-Rotolo, Megan, Everson, Gregory T., Lawitz, Eric, Rustgi, Vinod, Gardiner, David F., Bourlière, Marc   +21 more
core   +1 more source

Beclabuvir in combination with asunaprevir and daclatasvir for hepatitis C virus genotype 1 infection: A systematic review and meta-analysis

, 2018
Daclatasvir, asunaprevir, and beclabuvir are direct-acting antivirals for patients with hepatitis C virus genotype 1 infection. This systematic review and meta-analysis investigating the efficacy and safety of this three-drug combination in HCV genotype ...
Duy Hieu Truong (3338097)
core   +1 more source

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy [PDF]

, 2018
Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological ...
Sakaguchi, Kosaku, Takaguchi, Koichi, Kubota, Junichi, Moriya, Akio, Miyatake, Hirokazu, Okada, Hiroyuki, Yasunaka, Tetsuya, Kawaguchi, Mitsuhiko, Kobashi, Haruhiko, Kariyama, Kazuya, Takayama, Hiroki, Iwasaki, Yoshiaki, Wada, Nozomu, Morimoto, Yoichi, Ikeda, Fusao, Takeuchi, Yasuto, Hashimoto, Noriaki, Hagihara, Hiroaki, Mori, Chizuru, Fujioka, Shin-ichi, Takaki, Akinobu   +20 more
core   +1 more source

A case with acute-on-chronic liver failure receiving liver transplantation during daclatasvir and asunaprevir therapy in chronic hepatitis C patient

, 2018
We report a case with hepatitis C virus genotype 1 b liver cirrhosis who received liver transplantation because of acute-on-chronic liver failure during daclatasvir (DSV) and asunaprevir (ASV) combination therapy. To our knowledge, this is the first case
Jihwan Jung, Soo Hyun Yang, Danbi Lee, Hyo Jeong Kang, Wonhyeong Park   +4 more
core   +1 more source