Results 61 to 70 of about 536 (130)

Strategies for Biomethane Purification: A Critical Review and New Approaches

GCB Bioenergy, Volume 17, Issue 5, May 2025.
ABSTRACT The global shift towards clean energy emphasizes waste valorization as a key to achieving sustainable development goals. Biomethane production from organic waste not only converts waste to energy but also reduces greenhouse gas emissions. The growth trajectory of sustainability and environmental protection highlights the significance of energy
Lolo Errol Molatudi, Thokozani Justin Kunene, Tebogo Mashifana   +2 more
wiley   +1 more source

A case with acute-on-chronic liver failure receiving liver transplantation during daclatasvir and asunaprevir therapy in chronic hepatitis C patient

, 2018
We report a case with hepatitis C virus genotype 1 b liver cirrhosis who received liver transplantation because of acute-on-chronic liver failure during daclatasvir (DSV) and asunaprevir (ASV) combination therapy. To our knowledge, this is the first case
Jihwan Jung, Soo Hyun Yang, Danbi Lee, Hyo Jeong Kang, Wonhyeong Park   +4 more
core   +1 more source

Thrombospondin 2 as a Predictive Biomarker for HCC in Hepatitis C Patients: A Longitudinal Study Following DAA Therapy

Journal of Viral Hepatitis, Volume 32, Issue 4, April 2025.
ABSTRACT This multicentre study investigated the dynamics of thrombospondin 2 (TSP2) levels during direct‐acting antiviral (DAA) therapy in hepatitis C virus (HCV) infected patients and evaluated TSP2's potential as a predictive marker for hepatocellular carcinoma (HCC).
Takanobu Iwadare, Takefumi Kimura, Ayumi Sugiura, Taiki Okumura, Shun‐ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Tomoo Yamazaki, Satoru Joshita, Naoki Tanaka, Takeji Umemura   +10 more
wiley   +1 more source

Rapid, direct, and sensitive determination of aziridine and 2-chloroethylamine by hydrophilic interaction liquid chromatography-mass spectrometry

MethodsX, 2019
A rapid HILIC-MS method was developed for measuring the genotoxic impurities aziridine and 2-chloroethylamine. Sample preparation was simple and direct without requiring derivatization.
Jonathan G. Shackman
doaj   +1 more source

Engineering strategies to mitigate toxicities associated with CAR‐T cell therapy

BMEMat, Volume 3, Issue 1, March 2025.
This review provides a brief overview of several of the major, and potentially life‐threatening, toxicities associated with CAR T cell therapies and discusses various examples of the genetic and chemical engineering strategies employed to effectively mitigate such toxicities in preclinical models and clinical studies. Abstract Chimeric antigen receptor
Tyler Wolter, Yixin Wang, Quanyin Hu
wiley   +1 more source

New Insights Into Hepatic Impairment (HI) Trials

Clinical and Translational Science, Volume 18, Issue 1, January 2025.
ABSTRACT Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. This review aimed at looking into the data from dedicated HI studies, cluster these data into various categories and connect the effect by ...
Sebastian Haertter, Maximilian Lobmeyer, Brian C. Ferslew, Pallabi Mitra, Thomas Arnhold   +4 more
wiley   +1 more source

A Hepatitis C Virus-Associated Chronic Hepatitis Patient Developing Various Adverse Events Including Severe Gingivitis, Gingival Bleeding, and Inflammation of Genital Vulva during the Course of Antiviral Therapy with Elbasvir/Grazoprevir

Case Reports in Gastroenterology, 2017
Oral direct-acting antivirals comprise the main therapy for hepatitis C virus (HCV)-associated liver disease in Japan. Daclatasvir/asunaprevir is the primary agent and sofosbuvir/ledipasvir is the secondary agent for HCV genotype 1b.
Kazuo Tarao, Akira Sato
doaj   +1 more source

Chemogenetic Tools in Focus: Proximity, Conformation, and Sterics

Chemistry–Methods, Volume 4, Issue 6, June 2024.
Chemogenetic tools have been widely applied to interrogate dynamic biological processes. They are genetically encoded systems that are controlled by user‐defined chemicals. In this review, chemogenetic tool designs for various biological applications are introduced and discussed.
Jiaqi Shen, Guanwei Zhou, Wenjing Wang
wiley   +1 more source

HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy

Viruses, 2015
Sustained virological response (SVR) rates have increased dramatically following the approval of direct acting antiviral (DAA) therapies. While individual DAAs have a low barrier to resistance, most patients can be successfully treated using DAA ...
Kazuaki Chayama, C. Nelson Hayes
doaj   +1 more source

Efficacy and safety of a fixed dose combination tablet of asunaprevir + beclabuvir + daclatasvir for the treatment of Hepatitis C

, 2020
Introduction: Hepatitis C virus (HCV) is estimated to infect approximately 70 million people worldwide. If left untreated, chronic infection can progress to cirrhosis, liver failure or hepatocellular carcinoma. The advent of new direct-acting antivirals (
Zappulo E., Scotto R., Pinchera B., Gentile I., Buonomo A. R., Maraolo A. E.   +5 more
core   +1 more source