Results 71 to 80 of about 1,165,955 (283)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

On Models of New Physics for the Tevatron Top A_FB [PDF]

open access: yes, 2011
CDF has observed a top forward-backward asymmetry discrepant with the Standard Model prediction at 3.4 \sigma. We analyze models that could generate the asymmetry, including flavor-violating W's, horizontal Z'_Hs, triplet and sextet diquarks, and ...
Gresham, Moira I.   +2 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Origins of the di-jet asymmetry in heavy ion collisions

open access: yes, 2015
The di-jet asymmetry --- the measure of the momentum imbalance in a di-jet system --- is a key jet quenching observable. Using the event generator \jewel we show that the di-jet asymmetry is dominated by fluctuations both in proton-proton and in heavy ...
Milhano, José Guilherme   +1 more
core   +1 more source

Flavour Matters in Leptogenesis [PDF]

open access: yes, 2006
We give analytic approximations to the baryon asymmetry produced by thermal leptogenesis with hierarchical right-handed neutrinos. Our calculation includes flavour-dependent washout processes and CP violation in scattering, and neglects gauge ...
A. Abada   +15 more
core   +4 more sources

EEG-based major depressive disorder recognition by neural oscillation and asymmetry

open access: yesFrontiers in Neuroscience
BackgroundMajor Depressive Disorder (MDD) is a pervasive mental health issue with significant diagnostic challenges. Electroencephalography (EEG) offers a non-invasive window into the neural dynamics associated with MDD, yet the diagnostic efficacy is ...
Xinyu Liu   +18 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

On Higgs and sphaleron effects during the leptogenesis era

open access: yes, 2005
We discuss the effects of various processes that can be active during the leptogenesis era, and present the Boltzmann equations that take them into account appropriately.
E. Nardi   +6 more
core   +1 more source

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