Results 71 to 80 of about 189,792 (145)

Ultrasound Features of the First Metatarsophalangeal Joint in Gout and Asymptomatic Hyperuricemia: Comparison With Normouricemic Individuals [PDF]

, 2016
Objective The first metatarsophalangeal (MTP1) joint is frequently affected in gout. The aim of this study was to identify ultrasound features of the MTP1 joint in people with gout and people with asymptomatic hyperuricemia compared with normouricemic
Vandal, AV, Rome, K, Rhian, M, Dalbeth, N, Allen, B, Stewart, S, Keith Rome, Nicola Dalbeth, Bruce Allen, Miranda, R, Alain C. Vandal, Rhian Miranda, Vandal, AC, Sarah Stewart   +13 more
core   +1 more source

Multifaceted hyperuricemia: modern approaches to diagnosis from the asymptomatic stage and the choice of treatment strategy

, 2021
On May 24, 2021, within the framework of the IX Eurasian Congress of Cardiology, a symposium «Multifaceted Hyperuricemia»was held online with the assistance of the Egis company.
I. V. Kovaleva, И.В. Ковалёва
core   +1 more source

Bioequivalence of Two Firsekibart Subcutaneous Formulations: A Randomized, Double‐Blind, Single‐Dose, Parallel‐Group Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 7, July 2026.
Abstract We evaluated the pharmacokinetic (PK) bioequivalence and safety of a new formulation of firsekibart (solution for injection) compared with firsekibart lyophilized powder for solution. In this randomized, double‐blind, parallel‐group study, healthy Chinese adult males received a single subcutaneous dose of 200 mg firsekibart solution for ...
Yehua Xie, Xiao Li, Yushi Chen, Guangli Ma, Fei Gu, Yuling Lian, Xu Zhang, Xiaolan Yong   +7 more
wiley   +1 more source

DataSheet1_Effect of Urate-Lowering Therapy on the Progression of Kidney Function in Patients With Asymptomatic Hyperuricemia: A Systematic Review and Meta-Analysis.docx

, 2022
Background: Hyperuricemia is involved in the risk of chronic kidney disease (CKD). However, whether urate-lowering therapy (ULT) can influence the progression of kidney function in patients with asymptomatic hyperuricemia is still controversial.
Kang An (1710322), Qiaoli Su (11957870), Lin Zhang (8926), Mei Zhang (46138), Xingyu Mou (11473951), Shuangqing Li (8687505)   +5 more
core   +1 more source

Sex difference in the risk of coronary artery calcification progression related to hyperuricemia among asymptomatic 12,316 Korean adults

Scientific Reports
Data on hyperuricemia-related changes in coronary atherosclerosis are limited, especially in sex difference. This study evaluated the association between hyperuricemia and coronary artery calcification (CAC) progression in asymptomatic Korean men and ...
Ki-Bum Won, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Jidong Sung, Hae Ok Jung, Hyuk-Jae Chang   +6 more
doaj   +1 more source

Xanthine oxidase inhibitors in asymptomatic hyperuricemia

Современная ревматология, 2019
Asymptomatic hyperuricemia (AHU) is a condition, in which the serum concentration of uric acid (UA) is increased (>420 μmol/l in men or >360 μmol/l in women) and there are no signs of the formation of urate crystals.
O. V. Zhelyabina, M. S. Eliseev
doaj   +1 more source

Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
This review shows that CGM can shift GSD management from reactive surveillance to proactive metabolic regulation, significantly improving Time in Range. While effective in detecting occult hypoglycemia, its clinical utility is currently limited by low‐range sensor inaccuracies and alarm fatigue, necessitating individualized patient management. ABSTRACT
Reihaneh Mohsenipour, Farzaneh Abbasi, Maryam Sadat Ghaderian, Asal Khalili Dehkordi, Saeideh Abdolahpour, Kasra Akbari   +5 more
wiley   +1 more source

Clinical characteristics in control subjects and patients with asymptomatic hyperuricemia, gouty arthritis without tophi, and tophaceous gout.

, 2014
Data are expressed as mean± standard deviation or number (percentage). Stage 0: age-match control, Stage I: asymptomatic hyperuricemia, Stage II: gouty arthritis without tophi, Stage III: tophaceous gout ...
Jen-Te Hsu (633871), Chang-Min Chung (633870), Jing-Chi Lin (633867), Kuo-Li Pan (633866), Chun-Liang Lin (406448), Mien-Cheng Chen (633868), Shih-Tai Chang (633869)   +6 more
core   +1 more source

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real‐World Data Screening and in Vitro Validation

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Drug repositioning analysis identifies candidate therapeutic agents for Alzheimer’s diseaseand supports further mechanistic and translational investigation. ABSTRACT Drug development for Alzheimer's disease (AD) remains challenging, with only a 0.4% success rate from Phase I trials to regulatory approval.
Sho Sakagami, Yuya Yoshida, Shota Uemura, Taisei Kumamoto, Ryotaro Tsukamoto, Takumi Nishi, Shimpei Kawano, Kohei Fukuoka, Hanami Ino, Kengo Hamamura, Shigehiro Ohdo, Naoya Matsunaga   +11 more
wiley   +1 more source