Results 51 to 60 of about 360,965 (150)

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole–Pyrazole Hybrid Scaffolds as Multi‐Target Anti‐Ulcer Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The hybrid pharmacophore approach involves the combination of benzimidazole‐pyrazole moieties to form multi‐functional anti‐ulcer compounds. Molecular modeling and biological evaluations show significant proton pump inhibition, anti‐inflammatory action, antioxidant property, and remarkable prevention of gastric ulcers.
Hafiz Aamir Ali Kharl, Abdul Malik, Humaira Nadeem, Mohammad Shamsul Ola, Sara Aiman, Arif Ullah Khan, Muhammad Akmal Farooq, Humaira Muzaffar, Syed Muzzammil Masaud   +8 more
wiley   +1 more source

Therapeutic benefit of mesenchymal stem cells in pregnant rats with angiotensin receptor agonistic autoantibody-induced hypertension: Implications for immunomodulation and cytoprotection

Hypertension in Pregnancy, 2017
Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus.
Dan Zhang, Lihua Fu, Leilei Wang, Lin Lin, Lihong Yu, Lijun Zhang, Tao Shang   +6 more
doaj   +1 more source

Transglutaminase is a Critical Link Between Inflammation and Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe pathogenesis of essential hypertension is multifactorial with different underlying mechanisms contributing to disease. We have recently shown that TNF superfamily member 14 LIGHT (an acronym for homologous to lymphotoxins, exhibits ...
Renna Luo, Chen Liu, Serra E. Elliott, Wei Wang, Nicholas Parchim, Takayuki Iriyama, Patrick S. Daugherty, Lijian Tao, Holger K. Eltzschig, Sean C. Blackwell, Baha M. Sibai, Rodney E. Kellems, Yang Xia   +12 more
doaj   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Preeclampsia, Autoimmunity and The At1 Receptor [PDF]

, 2010
Preeclampsia (PE) is a disease of late pregnancy characterized by maternal hypertension and proteinuria. It is associated with preterm delivery and significant perinatal morbidity and mortality.
Irani, Roxanna A
core   +1 more source

Non-HLA angiotensin-type-1 receptor autoantibodies mediate the long-term loss of grafted neurons in Parkinson’s disease models

Stem Cell Research & Therapy
Background Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviate motor symptoms in Parkinson´s disease (PD).
Ana I. Rodríguez-Pérez, Pablo Garrido-Gil, Maria García-Garrote, Ana Muñoz, Juan A. Parga, Jose Luis Labandeira-García, Jannette Rodríguez-Pallares   +6 more
doaj   +1 more source

TLR7 Agonist Nanomedicine Suppresses Lung Metastasis of Osteosarcoma by Remodeling the Immune Microenvironment

MedComm – Oncology, Volume 5, Issue 3, September 2026.
In tail‐vein and orthotopic osteosarcoma mouse models, 1V209‑Cho‑Lip, a TLR7 agonist liposome, effectively suppresses pulmonary metastasis and prolongs survival. Flow cytometry and single‑cell transcriptomics reveal that 1V209‑Cho‑Lip remodels both the pre‑metastatic and post‑metastatic immune microenvironments, alleviates myeloid‑mediated ...
Xinyue Zhang, Hao Zeng, Furong Qin, Yuquan Wei, Dandan Wan, Xiawei Wei   +5 more
wiley   +1 more source

MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago – Sinorhizobium symbiosis

New Phytologist, Volume 251, Issue 5, Page 2867-2887, September 2026.
MtSymCRK–MtGRF8‐14‐3‐3a, e, h and i functional model in R‐108 nodules. Summary In Medicago littoralis R‐108, Symbiotic CYSTEINE‐RICH RECEPTOR‐LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection.
Chaoyan Yin, Kévin Magne, Fathi Berrabah, Dario Monachello, Gautier Bernal, Kirankumar S. Mysore, Jiangqi Wen, Catherine Etchebest, Pascal Ratet, Véronique Gruber   +9 more
wiley   +1 more source

Agonistic AT1 receptor autoantibodies and monocyte stimulation in hypertensive patients

, 2003
Background Agonistic AT1 receptor autoantibodies (AT1-AA) have been described in hypertensive and preeclamptic patients. Furthermore, monocytes are activated in hypertensive patients.
Homuth, V., Herberg, M., Doerffel, W., Doerffel, Y., Bochnig, N., Scholze, J., Chaoui, R., Wallukat, G., Pruss, A.   +8 more
core   +1 more source

Polymorphism of the second type angiotensin II receptor’s gene in women with essential hypertension and the corresponding features of structural and functional parameters of myocardium

Patologìâ, 2018
Objective. To improve the diagnosis of predisposition to Essential arterial hypertension (EH) and Chronic heart failure (CHF) in postmenopausal age’s women by determining the polymorphic genotypes of the first type angiotensin II receptor’s gene (AT1-R)
O. O. Sakovych, V. M. Zhebel, T. V. Polishchuk, S. V. Franchuk, L. M. Sursaieva   +4 more
doaj   +1 more source