Results 31 to 40 of about 360,965 (150)

Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia

Biology of Sex Differences, 2021
Women with preeclampsia (PE) have a greater risk of developing hypertension, cardiovascular disease (CVD), and renal disease later in life. Angiotensin II type I receptor agonistic autoantibodies (AT1-AAs) are elevated in women with PE during pregnancy ...
George W. Booz, Daniel Kennedy, Michael Bowling, Taprieka Robinson, Daniel Azubuike, Brandon Fisher, Karen Brooks, Pooja Chinthakuntla, Ngoc H. Hoang, Jonathan P. Hosler, Mark W. Cunningham   +10 more
doaj   +1 more source

Archetypal analysis of longitudinal visual fields for idiopathic intracranial hypertension patients presenting in a clinic setting.

PLOS Digital Health, 2023
We previously applied archetypal analysis (AA) using visual fields (VF) from the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) to derive a model, which quantified patterns (or archetypes [ATs] of VF loss), anticipated recovery, and ...
Joseph Branco, Tobias Elze, Jui-Kai Wang, Louis R Pasquale, Mona K Garvin, Randy Kardon, Mark J Kupersmith   +6 more
doaj   +1 more source

Preparation and Biological Activity of the Monoclonal Antibody against the Second Extracellular Loop of the Angiotensin II Type 1 Receptor

Journal of Immunology Research, 2016
The current study was to prepare a mouse-derived antibody against the angiotensin II type 1 receptor (AT1-mAb) based on monoclonal antibody technology, to provide a foundation for research on AT1-AA-positive diseases.
Mingming Wei, Chengrui Zhao, Suli Zhang, Li Wang, Huirong Liu, Xinliang Ma   +5 more
doaj   +1 more source

Auricular Acupuncture for Exam Anxiety in Medical Students-A Randomized Crossover Investigation. [PDF]

PLoS ONE, 2016
Auricular acupuncture (AA) is effective in the treatment of preoperative anxiety. The aim was to investigate whether AA can reduce exam anxiety as compared to placebo and no intervention. Forty-four medical students were randomized to receive AA, placebo,
Catharina Klausenitz, Henriette Hacker, Thomas Hesse, Thomas Kohlmann, Karlhans Endlich, Klaus Hahnenkamp, Taras Usichenko   +6 more
doaj   +1 more source

Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons

Frontiers in Immunology
Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson’s disease (PD).
Lucia Lage, Ana I. Rodríguez-Perez, Ana I. Rodríguez-Perez, Jose L. Labandeira-Garcia, Jose L. Labandeira-Garcia, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide   +6 more
doaj   +1 more source

Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Preeclampsia (PE) is a life‐threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1‐AA, that activate the AT1 angiotensin receptor.
Chen Liu, Renna Luo, Serra E. Elliott, Wei Wang, Nicholas F. Parchim, Takayuki Iriyama, Patrick S. Daugherty, Sean C. Blackwell, Baha M. Sibai, Rodney E. Kellems, Yang Xia   +10 more
doaj   +1 more source

Angiotensin Ⅱ type 1 receptor autoantibody-AT1R-Bmal1 axis promotes phenotypic transition of vascular smooth muscle cells and vascular fibrosis

陆军军医大学学报
‍Objective‍　‍To investigate the mechanism by which angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) promotes phenotypic switch of vascular smooth muscle cells (VSMCs) and vascular fibrosis through abnormal expression of circadian clock protein BMAL1.
XUE Lingxia, LONG Yaolin, FENG Jiayan
doaj   +1 more source

The dopamine receptor D4 regulates the proliferation of pulmonary arteries smooth muscle in broilers by downregulating AT1R

Animal Diseases, 2021
The major cause of pulmonary vascular remodeling in broilers is abnormal proliferation of vascular smooth muscle cells (VSMCs), and one of the main causes of pulmonary hypertension syndrome (PHS) in broilers is pulmonary artery vascular remodeling. Forty
Xiaoqi Yang, Yang Fu, Lianfeng Wu, Antong Li, Luyao Ji, Hao Li, Yuxuan Peng, Jiabin Zhang, Donghai Zhou, Huiping Zhou   +9 more
doaj   +1 more source

Association between AT1 receptor gene polymorphism and left ventricular hypertrophy and arterial stiffness in essential hypertension patients: a prospective cohort study

BMC Cardiovascular Disorders, 2022
Background AT1 receptor gene (AGTR1) is related to essential hypertension (EH), and left ventricular hypertrophy (LVH) and arterial stiffness are common complications of EH.
Hangjun Ou, Danan Liu, Guangjian Zhao, Caiwei Gong, Yunyun Li, Quanwei Zhao   +5 more
doaj   +1 more source

Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertension

, 2011
Background: Agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) and reactive oxygen species (ROS) are implicated in the pathophysiology of preeclampsia.
Ray, L.F., Martin, J.N., Cockrell, K., G. Wallukat, L. F. Ray, Weimer, A., R. Dechend, Parrish, M.R., Wenzel, K., B. LaMarca, K. Wenzel, Herse, F., M. R. Parrish, A. Weimer, M. Arany, K. Wallace, Arany, M., Tam Tam, K.B., Lamarca, B., Wallace, K., Wallukat, G., Dechend, R., K. Cockrell, K. B. T. Tam, J. N. Martin, F. Herse   +25 more
core   +1 more source