Results 11 to 20 of about 360,965 (150)

Renal natural killer cell activation and mitochondrial oxidative stress; new mechanisms in AT1-AA mediated hypertensive pregnancy [PDF]

Pregnancy Hypertension, 2019
Women with preeclampsia (PE) have increased mean arterial pressure (MAP), natural killer (NK) cells, reactive oxygen species (ROS), and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA).
Lorena Amaral, Babbette LaMarca, Denise C Cornelius   +2 more
exaly   +3 more sources

AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum. [PDF]

Int J Cerebrovasc Dis Stroke, 2023
Preeclampsia (PE), new-onset hypertension during pregnancy alongside organ dysfunction, is a leading cause of morbidity and mortality for the mother and fetus.
Campbell N, Strong L, Fang X, Border JJ, Herrock O, Turner T, Deer E, Amaral L, Dechend R, Roman RJ, LaMarca B.   +10 more
europepmc   +2 more sources

Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia [PDF]

BMC Pregnancy and Childbirth
Background Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been ...
Laure Ponthier, Chahrazed El Hamel, Perrine Coste Mazeau, Sophie Martinez, Sarah Wehbe, Rachel Froget, Catherine Yardin, Vincent Guigonis   +7 more
doaj   +2 more sources

B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia.

Am J Physiol Renal Physiol, 2023
Preeclampsia, new onset hypertension during pregnancy, is associated with activated T helper cells (Th) and B cells secreting agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AA).
Herrock OT, Deer E, Amaral LM, Campbell N, Lemon J, Ingram N, Cornelius DC, Turner TW, Fitzgerald S, Ibrahim T, Dechend R, Wallukat G, LaMarca B.   +12 more
europepmc   +2 more sources

Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome. [PDF]

Sci Rep, 2018
HELLP syndrome remains a leading cause of maternal and neonatal mortality and morbidity worldwide, which symptoms include hemolysis, elevated liver enzymes and low platelet count.
Bu S, Wang Y, Sun S, Zheng Y, Jin Z, Zhi J.   +5 more
europepmc   +2 more sources

AT1-AA induced hypertension during pregnancy contributes to developmental programming of hypertension in female offspring. [PDF]

J Reprod Immunol
Preeclampsia (PE), new-onset hypertension during pregnancy, is accompanied by organ dysfunction, in addition to placental dysfunction, and is associated with chronic inflammation and fetal growth restriction.
Campbell N, Lemon JP, Helmich M, Solise D, Demesa A, Goolsby E, LaMarca E, Deer E, Cornelius DC, Turner T, Amaral LM, Zheng B, LaMarca B.   +12 more
europepmc   +2 more sources

The Role of Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor (AT1-AA) in Pathophysiology of Preeclampsia [PDF]

Current Pharmaceutical Biotechnology, 2018
Babbette LaMarca, Nathan Campbell
exaly   +2 more sources

Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension.

Am J Physiol Regul Integr Comp Physiol, 2017
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE.
Faulkner JL, Amaral LM, Cornelius DC, Cunningham MW, Ibrahim T, Heep A, Campbell N, Usry N, Wallace K, Herse F, Dechend R, LaMarca B.   +11 more
europepmc   +2 more sources

Maternal treatment with agonistic autoantibodies against type-1 angiotensin II receptor in late pregnancy increases apoptosis of myocardial cells and myocardial susceptibility to ischemia-reperfusion injury in offspring rats. [PDF]

PLoS ONE, 2013
Epidemiological studies have demonstrated that offspring born to mothers preeclampsia (PE) are at increased risk for developing cardiovascular diseases after birth, but the underlying mechanism is unknown. Angiotensin II receptor type 1 autoantibody (AT1-
Zhu Jin, Wenhui Zhang, Hailiang Yang, Xiaofang Wang, Yanqian Zheng, Qiaoyan Zhang, Jianming Zhi   +6 more
doaj   +1 more source

AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats. [PDF]

Hypertension, 2018
Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive mechanisms (ET [endothelin] and sFlt-1 [soluble fms-like
Cunningham MW, Castillo J, Ibrahim T, Cornelius DC, Campbell N, Amaral L, Vaka VR, Usry N, Williams JM, LaMarca B.   +9 more
europepmc   +2 more sources