Results 21 to 30 of about 360,965 (150)

Angiotensin System Autoantibodies Correlate With Routine Prognostic Indicators for COVID-19 Severity

Frontiers in Medicine, 2022
ObjectiveWe previously showed that angiotensin type-1 receptor and ACE2 autoantibodies (AT1-AA, ACE2-AA) are associated with COVID-19 severity. Our aim is to find correlations of these autoantibodies with routine biochemical parameters that allow an ...
Carmen M. Labandeira, Carmen M. Labandeira, Maria A. Pedrosa, Juan A. Suarez-Quintanilla, María Cortes-Ayaso, José Luis Labandeira-García, José Luis Labandeira-García, Ana I. Rodríguez-Pérez, Ana I. Rodríguez-Pérez   +8 more
doaj   +1 more source

Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia

Exploration of Medicine, 2022
Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA).
Kristin E. Reeve, Evangeline Deer, Lorena M. Amaral, Denise C. Cornelius, Owen Herrock, Ashlyn C. Harmon, Nathan Campbell, Sarah Fitzgerald, Tarek Ibrahim, Gerd Wallukat, Ralf Dechend, Babbette LaMarca   +11 more
doaj   +1 more source

Empagliflozin Ameliorates Preeclampsia and Reduces Postpartum Susceptibility to Adriamycin in a Mouse Model Induced by Angiotensin Receptor Agonistic Autoantibodies

Frontiers in Pharmacology, 2022
Preeclampsia (PE) is the leading cause of maternal and perinatal morbidity and mortality and also is a risk factor for cardiovascular and kidney disease later in life.
Ruonan Zhai, Yuan Liu, Jiahao Tong, Ying Yu, Lin Yang, Yong Gu, Yong Gu, Jianying Niu   +7 more
doaj   +1 more source

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia

Kidney & Blood Pressure Research, 2018
Background/Aims: Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension.
Ying Yu, Lihong Zhang, Guang Xu, Zhenghong Wu, Qian Li, Yong Gu, Jianying Niu   +6 more
doaj   +1 more source

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Michelson, G., Hilgers, K.F., Oehmer, S., Harazny, J., Delles, C., Schmieder, R.E.   +5 more
core   +1 more source

Antibodies against AT1 receptors are associated with vascular endothelial and smooth muscle function impairment: protective effects of hydroxysafflor yellow A. [PDF]

PLoS ONE, 2013
Ample evidence has shown that autoantibodies against AT1 receptors (AT1-AA) are closely associated with human cardiovascular disease. The aim of this study was to investigate mechanisms underlying AT1-AA-induced vascular structural and functional ...
Zhu Jin, Wenhui Zhang, Weiran Chai, Yanqian Zheng, Jianming Zhi   +4 more
doaj   +1 more source

IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy.

Am J Physiol Regul Integr Comp Physiol, 2012
Preeclampsia is associated with autoimmune cells T(H)17, secreting interleukin-17, autoantibodies activating the angiotensin II type I receptor (AT1-AA), and placental oxidative stress (ROS). The objective of our study was to determine whether chronic IL-
Dhillion P, Wallace K, Herse F, Scott J, Wallukat G, Heath J, Mosely J, Martin JN, Dechend R, LaMarca B.   +9 more
europepmc   +2 more sources

Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Angiotensin II type 1 receptor (AT1R) autoantibody (AT1‐AA) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II), AT1‐AA can induce vasoconstriction in a sustained manner, causing a ...
Jingwei Bian, Jinghui Lei, Xiaochen Yin, Pengli Wang, Ye Wu, Xiaoli Yang, Li Wang, Suli Zhang, Huirong Liu, Michael L. X. Fu   +9 more
doaj   +1 more source

Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting

BMJ Open Ophthalmology, 2022
Background/aims We previously used archetypal analysis (AA) to create a model that quantified patterns (archetypes (ATs)) of visual field (VF) loss that can predict recovery and reveal residual VF deficits from eyes in the Optic Neuritis Treatment Trial (
Mark J Kupersmith, Louis R Pasquale, Randy Kardon, Tobias Elze, Joseph Branco, Jui-Kai Wang, Mona K Garvin   +6 more
doaj   +1 more source

Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia

Hypertension in Pregnancy, 2020
Introduction:Women with preeclampsia (PE) and reduced uterine perfusion pressure (RUPP) pre-clinical rat model of PE have elevated angiotensin II type 1 receptor agonistic autoantibodies (AT1-AA) and cerebrovascular dysfunction.
Jeremy W. Duncan, Daniel Azubuike, George W. Booz, Brandon Fisher, Jan M. Williams, Fan Fan, Tarek Ibrahim, Babbette LaMarca, Mark W. Cunningham   +8 more
doaj   +1 more source