Results 1 to 10 of about 3,905 (117)

miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells [PDF]

Acta Biochimica et Biophysica Sinica, 2023
Vascular inflammation induced by angiotensin II-1 receptor autoantibody (AT1-AA) is involved in the occurrence and development of various cardiovascular diseases.
Li Yang, Long Yaolin, Zhi Xiaoyan, Hao Haihu, Wang Xiaohui, Liu Huirong, Wang Li   +6 more
doaj   +2 more sources

Relationship between β1-AA and AT1-AA and Cardiac Function in Patients with Hypertension Complicated with Left Ventricular Diastolic Function Limitation [PDF]

Cardiovascular Therapeutics, 2023
Objective. To investigate the association between β1 adrenergic receptor autoantibodies (β1-AA) and angiotensin II type-1 receptor autoantibodies (AT1-AA) and cardiac function in patients with hypertension complicated with left ventricular diastolic ...
Liang Wang, Xue-Bai Lv, Yu-Ting Yuan, Ning Wang, Hong-Ying Yao, Wen-Chao Zhang, Peng-Fei Yin, Xiao-Hui Liu   +7 more
doaj   +2 more sources

AT1‐AA Is Produced in Offspring in Response to Placental Ischemia and Is Lowered by B‐Cell Depletion Without Compromising Overall Offspring Health [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Preeclampsia, new‐onset hypertension during pregnancy alongside other organ dysfunction, is the leading cause of mortality for the mother and low birth weight for the baby.
Nathan Campbell, Evangeline Deer, Dylan Solise, Denise C. Cornelius, Ty Turner, Lorena M. Amaral, Owen Herrock, Ariel Jordan, Shivani Shukla, Tarek Ibrahim, Babbette LaMarca   +10 more
doaj   +2 more sources

Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model [PDF]

Journal of Taibah University Medical Sciences, 2017
Objectives: Preeclampsia affects 3%–8% of all pregnancies. Thymoquinone is the primary compound in black cumin (Nigella sativa) and may have potential therapeutic effects in preeclampsia. This research analyses the effects of a black cumin seed ethanol
Humaira Rahma, Sp.OG, I.W.A. Indrawan, Sp.OG, Mukhamad Nooryanto, Sp.OG, Rahajeng, Sp.OG, Kusnarman Keman, Sp.OG   +4 more
doaj   +2 more sources

Role of agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) in pathogenesis of preeclampsia [PDF]

Global Medical Genetics
Preeclampsia(PE) is the most prevalent complication during pregnancy and constitutes a significant cause of morbidity and mortality among pregnant women and their fetuses. Recent studies have demonstrated elevated levels of angiotensin II type 1 receptor
Jing Wang, Lijuan Shan, Yanhui Zhao, Hongwen Cao, Shuhai Lan, Yizi Yan   +5 more
doaj   +2 more sources

Circulating levels of sFlt-1 and AT1-AA in women with prior preeclampsia: a 10-year postpartum cross-sectional analysis (PERLA-Brazil study) [PDF]

Scientific Reports
This study investigated whether soluble fms-like tyrosine kinase-1 (sFlt-1) and angiotensin II type 1 receptor autoantibodies (AT1-AA) – key mediators of preeclampsia (PE) pathophysiology – remain elevated ten years postpartum, thereby contributing to ...
Thaíse Emilia Moreira da Silva, Isabella Macedo Costa, Ana Paula Silva Ferreira, Thays Santos da Costa, Luiza Oliveira Perucci, Juliano Armstrong Arnosti, Luci Maria Sant’Ana Dusse, Jussara Mayrink, Patrícia Nessralla Alpoim   +8 more
doaj   +2 more sources

AT1R autoantibody impedes fetal hepatic glycogen synthesis by inhibiting PI3K/AKT signaling pathway during late gestation [PDF]

Journal of Translational Medicine
Background Fetal hepatic glycogen is essential for intrauterine development and postnatal metabolic adaptation. This study aimed to explore the impact of intrauterine exposure to angiotensin II type 1 receptor autoantibodies (AT1-AA) on fetal hepatic ...
Jingwei Bian, Wang Wang, Pengli Wang, Lina Bai, Chunyu He, Mingming Yue, Xiang Cheng, Huirong Liu, Suli Zhang   +8 more
doaj   +2 more sources

Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients [PDF]

Frontiers in Immunology
IntroductionDysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by
Ana I. Rodriguez-Perez, Ana I. Rodriguez-Perez, Ana I. Rodriguez-Perez, Gemma Serrano-Heras, Carmen M. Labandeira, Laura Camacho-Meño, Beatriz Castro-Robles, Juan A. Suarez-Quintanilla, Juan A. Suarez-Quintanilla, Mónica Muñoz-López, Mónica Muñoz-López, Pepa Piqueras-Landete, María J. Guerra, María J. Guerra, María J. Guerra, Tomas Segura, Tomas Segura, Tomas Segura, José L. Labandeira-Garcia, José L. Labandeira-Garcia, José L. Labandeira-Garcia   +20 more
doaj   +2 more sources

Renin–Angiotensin System Autoantibody Network in Parkinson’s Disease Patients [PDF]

Antioxidants
The tissue renin–angiotensin system (RAS) is a regulator of oxidative and inflammatory homeostasis by balancing its pro-oxidative/pro-inflammatory axis (angiotensin II, AngII, and AngII type-1 receptor, AT1) and its anti-oxidative/anti-inflammatory axis (
Carmen M. Labandeira, Laura Camacho-Meño, Paula Aracil-Pastor, Juan A. Suárez-Quintanilla, Jose L. Labandeira-García, Ana I. Rodríguez-Pérez   +5 more
doaj   +2 more sources

Decoding the immunological triad of TLRs, B1 cells, and feto-maternal microchimerism in pre-eclampsia pathogenesis: a narrative review [PDF]

Frontiers in Immunology
Pre-eclampsia (PE) is a pregnancy-specific hypertensive disorder with fatal consequences for maternal and foetal health, including placental abruption, foetal growth restriction, and foetal death. Its global prevalence is estimated at 2-8%.
Maithreyi Chandan Nair, Kesar Chandel, Shreevarsha S., Sneha Premraj, Nithya U., Gayathri M.   +5 more
doaj   +2 more sources