Results 21 to 30 of about 36,768 (197)

Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death

Frontiers in Immunology, 2023
IntroductionThe pathogenesis of chronic lung diseases is multifaceted with a major role of recurrent micro-injuries of the epithelium. While several reports clearly indicated a prominent role for surfactant-producing alveolar epithelial type 2 (AT2 ...
Sandra Carignon, Dorian De Moura Rodrigues, David Gosset, Elodie Culerier, Sarah Huot-Marchand, Florence Savigny, Eric Kaya, Valerie Quesniaux, Aurélie Gombault, Isabelle Couillin, Bernhard Ryffel, Marc Le Bert, Nicolas Riteau   +12 more
doaj   +1 more source

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Journal of Neuroinflammation, 2012
Background Several recent studies have shown that angiotensin type 1 receptor (AT1) antagonists such as candesartan inhibit the microglial inflammatory response and dopaminergic cell loss in animal models of Parkinson's disease.
Garrido-Gil Pablo, Joglar Belen, Rodriguez-Perez Ana I, Guerra Maria J, Labandeira-Garcia Jose L   +4 more
doaj   +1 more source

Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide

, 1999
In the present study, rats were immunized with angiotensin II receptor subtype 1 (AT1) receptor peptides for 3 months to see if the immunization produced specific anti-AT1 receptor antibodies and if continuous stimulation for 3 months affected blood ...
Schulze, W., Herlitz, H., Leung, P.S., Fu, M.L.X., Wallukat, G., Fu, H.M., Bergstroem, G.   +6 more
core   +2 more sources

Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys [PDF]

, 2014
Introduction. The renin granulation of kidney arterioles is enhanced in diabetes despite the fact that the level of angiotensin II in the diabetic kidney is elevated.
Rázga Zsolt, Bódi Nikolett, Kovács Gábor, Nyengaard Jens Randel, Talapka Petra   +4 more
core   +1 more source

Overexpression of AT1 receptor.

, 2021
AT1 expression in normal, hypoxic and hypertrophic H9c2 cells.
Susan Westfall (392141), Dominique Shum-Tim (1332057), Satya Prakash (9273), Nikita Lomis (6619463)   +3 more
core   +1 more source

Amphetamine Induces Oxidative Stress, Glial Activation and Transient Angiogenesis in Prefrontal Cortex via AT1-R

Frontiers in Pharmacology, 2021
Background: Amphetamine (AMPH) alters neurons, glia and microvessels, which affects neurovascular unit coupling, leading to disruption in brain functions such as attention and working memory.
Osvaldo M. Basmadjian, Victoria B. Occhieppo, Natalia A. Marchese, Natalia A. Marchese, M. Jazmin Silvero C., María Cecilia Becerra, Gustavo Baiardi, Gustavo Baiardi, Claudia Bregonzio   +8 more
doaj   +1 more source

Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons

Frontiers in Immunology
Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson’s disease (PD).
Lucia Lage, Ana I. Rodríguez-Perez, Ana I. Rodríguez-Perez, Jose L. Labandeira-Garcia, Jose L. Labandeira-Garcia, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide   +6 more
doaj   +1 more source

AZ AT1-R G-FEHÉRJE FÜGGETLEN JELÁTVITELÉNEK VIZSGÁLATA = G PROTEIN-INDEPENDENT SIGNALING OF AT1-R [PDF]

, 2011
Az angiotenzin II (AngII) a renin-angiotenzin rendszer fő szabályozója és nemcsak normál élettani szabályozási folyamatokban, hanem számos kórélettani folyamatban is szerepet játszik.
Balla, András
core   +1 more source

Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin II

, 2005
Angiotensin II (AngII) is considered as a cytokine-like factor displaying a variety of proinflammatory and profibrotic cellular effects. Most of these effects seem mediated by AT1 signaling, whereas AT2 expression and function in adult human cells remain
Santiago, Begoña, Galindo Izquierdo, María, Pablos Álvarez, José Luis, Ramírez Fernández, Juan Carlos, Palao, Guillermo, Gutiérrez Cañas, Irene   +5 more
core   +1 more source

Significance of Matrix Metalloproteinase-9 Inhibition by Imidapril for Prevention of Abdominal Aortic Aneurysms in Angiotensin II Type 1 Receptor–Knockout Mice

Journal of Pharmacological Sciences, 2013
To clarify the matrix metalloproteinase (MMP)-9 inhibitory effect of an angiotensin-converting enzyme (ACE) inhibitor in vivo, we evaluated the effect of an ACE inhibitor against elastase-induced abdominal aortic aneurysm (AAA) progression in mice ...
Shinji Takai, Denan Jin, Daisuke Yamamoto, Zhong-Lian Li, Yoshinori Otsuki, Mizuo Miyazaki   +5 more
doaj   +1 more source