Angiotensin II type 1 receptor antibodies as a contributor to microvascular inflammation in kidney transplant recipients: insights from statistical and artificial intelligence based approaches. [PDF]
Front ImmunolMizera J +6 more
europepmc +1 more source
Interplay of cholesterol, membrane bilayers and the AT1R: A cholesterol consensus motif on AT1R is revealed [PDF]
Computational and Structural Biotechnology Journal, 2021 Hypertension, mediated by the Angiotensin II receptor type 1 (AT1R), is still the major cause of premature death despite the discovery of novel therapeutics, highlighting the importance of an in depth understanding of the drug-AT1R recognition mechanisms coupled with the impact of the membrane environment on the interaction of drugs with AT1R.
Sofia Kiriakidi +2 more
exaly +7 more sources
The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy [PDF]
FEBS Letters, 2005 Activation of angiotensin II (Ang II) type 1 receptor (AT1R) signaling is reported to play an important role in cardiac hypertrophy. We previously cloned a novel molecule interacting with the AT1R, which we named ATRAP (for Ang II type 1 receptor‐associated protein).
Kouichi Tamura +2 more
exaly +4 more sources
AT1R Activating Autoantibodies in Hematopoietic Stem Cell Transplantation [PDF]
Biology of Blood and Marrow Transplantation, 2020 Angiotensin II type 1 receptor activating autoantibodies (AT1R-AAs) have gained attention in solid organ transplant as non-HLA antibodies associated with rejection, vasculopathy, and graft dysfunction. These antibodies have also been reported in the context of pre-eclampsia, scleroderma, and isolated hypertension.
Meghan Pearl +2 more
exaly +6 more sources
Anti-AT1R autoantibodies and prediction of the severity of Covid-19
Human Immunology, 2022 The stimulation of AT1R (Angiotensin II Receptor Type 1) by Angiotensin II has, in addition to the effects on the renin-angiotensin system, also pro-inflammatory effects through stimulation of ADAM17 and subsequent production of INF-gamma and Interleukin-6.
Chiara Angeletti +2 more
exaly +4 more sources
Rational Design and Synthesis of AT1R Antagonists [PDF]
Molecules, 2021 Hypertension is one of the most common diseases nowadays and is still the major cause of premature death despite of the continuous discovery of novel therapeutics. The discovery of the Renin Angiotensin System (RAS) unveiled a path to develop efficient drugs to fruitfully combat hypertension.
Nikitas Georgiou +2 more
exaly +5 more sources
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Prevalence of AT1R antibody (AT1R-Ab) among Malaysian multi-ethnic population
Human Immunology, 2020Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions.
Maisarah Jalalonmuhali +2 more
exaly +3 more sources
Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance High-resolution structural knowledge is a key driver for discovering small molecules to target functional motifs in G protein-coupled receptors (GPCRs). Reports of autoantibodies targeting extracellular motifs of GPCRs are increasing with no therapies in sight.
Khuraijam Dhanachandra Singh +2 more
exaly +3 more sources
Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases
Molecules, 2022 International audienceThe binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the ...
Cedric Annweiler +2 more
exaly +2 more sources
Effect of AT1R knockdown on ishikawa cell proliferation induced by estrogen
Archives of Gynecology and Obstetrics, 2012This study aimed to study the effects of angiotensin receptor (AT1R) on proliferation, cell cycle progression, and apoptosis of estrogen-induced ishikawa cell by the transfection of AT1R-siRNA.Immunofluorescence method was used to detect AT1R in ishikawa cell.
Qing Yang, Fangfang Bi, Wang Guangwei
exaly +3 more sources