Results 141 to 150 of about 13,112 (166)

Staphylococcal nuclease domain containing‐1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling

FEBS Open Bio, 2014
Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells.
Prasanna K Santhekadur, Maaged A Akiel, Rachel Gredler   +2 more
exaly   +2 more sources

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Outcomes in Cardiac Transplant Recipients According to Pretransplant AT1R Antibody Levels and Donor AT1R Polymorphisms

The Journal of Heart and Lung Transplantation, 2015
s S183 artery operation. We found a statistically significant difference in BNP levels between groups (group A-mean level 2241 ng/l, group B 101,3ng/l, p< 0,001, Mann-Whitney test). All pts from group A suffered from at least one episode of decompensation, none from group B.
M. Zacharias, B. Hynes, N.K. Sweitzer, M.R. Johnson, S. Akhter, T. Ellis, R. Dhingra   +6 more
openaire   +1 more source

Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPARγ derived from the AT1R antagonist, Fimasartan

Bioorganic & Medicinal Chemistry Letters, 2018
Inspired by the well-known PPARγ partial agonism of angiotensin II type 1 receptor (AT1R) antagonists exemplified by an antihypertensive drug, Telmisartan, efforts to identify compounds with the dual activities have been pursued in order to control the two major metabolic disorders, hypertension and hyperglycemia simultaneously.
Wonken, Choung, Hui Jin, Jung, Eun Hye, Nam, Deokmo, Yang, Byoungwook, Yoo, Hyukjoon, Choi, Bo Ram, Lee, Min, Park, Su Min, Jang, Jae Soo, Lim, Kyung-Hee, Kim, Jungwook, Chin, Kyungjin, Jung, Geumwoo, Lee, Seong Heon, Kim   +14 more
openaire   +2 more sources

AT1R autoantibody promotes phenotypic transition of smooth muscle cells by activating AT1R-OAS2

Biochemical Pharmacology
Phenotypic transition of vascular smooth muscle cells (VSMCs) is an early event in the onset and progression of several cardiovascular diseases. As an important mediator of the renin-angiotensin system (RAS), activation of the angiotensin II type 1 receptor (AT1R) induces phenotypic transition of VSMCs.
Xi, Zhang, Bingjie, Li, Yingshuo, Yan, Fei, Sun, Suli, Zhang, Meili, Wang, Huirong, Liu   +6 more
openaire   +2 more sources

Anti-ETAR and anti-AT1R autoantibodies are elevated in patients with endstage cystic fibrosis

Journal of Cystic Fibrosis, 2015
Autoantibodies against endothelin-1 type A receptor (ETAR) are present in systemic sclerosis complicated by lung fibrosis and pulmonary hypertension. As increased serum levels and local overproduction of endothelin-1 in the airways are reported in cystic
J M Kwakkel-Van Erp, C E Hack, Henny G Otten   +2 more
exaly   +2 more sources

Anti-AT1R autoantibodies in pancreas transplantation

American Journal of Transplantation
Autoantibodies targeting the angiotensin II receptor type 1 (AT1R) have been identified as drivers of allograft vascular inflammation in kidney transplantation. We investigated the role of AT1R autoantibodies (AT1R-AA) in pancreas transplantation with a focus on rejection and thrombosis.
Masset, Christophe, Rousseau, Olivia, Walencik, Alexandre, Renaudin, Karine, Blandin, Stéphanie, Ambroset, Melodie, Gérard, Nathalie, Lorent, Marine, Degauque, Nicolas, Brouard, Sophie, Danger, Richard, Giral, Magali, Blancho, Gilles, Branchereau, Julien, Mesnard, Benoit, Cantarovich, Diego, Dantal, Jacques   +16 more
openaire   +3 more sources

Biased Agonist TRV027 Determinants in AT1R by Molecular Dynamics Simulations

Journal of Chemical Information and Modeling, 2019
Functional selectivity is a phenomenon observed in G protein-coupled receptors in which intermediate active-state conformations are stabilized by mutations or ligand binding, resulting in different sets of signaling pathways. Peptides capable of selectively activating β-arrestin, known as biased agonists, have already been characterized in vivo and ...
Silvestre Massimo Modestia, Matheus Malta de Sá, Eric Auger, Gustavo Henrique Goulart Trossini, José Eduardo Krieger, Carlota de Oliveira Rangel-Yagui   +5 more
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P193 Incidence of AT1R- antibody in women with hellp syndrome

Human Immunology, 2017
Aim Antibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been implicated in a number of disease processes, including development of fibrosis in cystic fibrosis and systemic sclerosis, antibody mediated rejection in solid organ transplantation and more recently frailty in an aging population.
Solange Eloundou, Arthur J. Vaught, Denise E. Kielek, Jennifer L. Metz, Mary Carmelle Philogene   +4 more
openaire   +1 more source

Effect of Bortezomib Desensitization Therapy on Levels of AT1R Antibody

The Journal of Heart and Lung Transplantation, 2019
Purpose Increased levels of angiotensin II type 1 receptor (AT1R) antibody have been shown to be associated with antibody mediated rejection (AMR), cell mediated rejection (CMR), and early onset of microvasculopathy at one year post heart transplant. MCS patients with the saturated levels of AT1R antibody also trend lower survival.
X. Zhang, J. Patel, J. Kobashigawa
openaire   +1 more source

P161 Autoantibodies: Angiotensinogen vs AT1R as a target, Is there a correlation?

Human Immunology, 2018
Aim Autoantibody directed at the Angiotensin II Type 1 Receptor (AT1R) has been reported as detrimental to solid organ transplants. An ELISA based AT1R antibody test is available, but presents challenges including different methodology, lot-to-lot variability, and cost effectiveness among them.
Leah Pittmon, Medhat Z. Askar
openaire   +1 more source