Results 141 to 150 of about 33,965 (276)

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks [PDF]

, 2007
Aprataxin and polynucleotide kinase (PNK) are DNA end processing factors that are recruited into the DNA single- and double-strand break repair machinery through phosphorylation-specific interactions with XRCC1 and XRCC4, respectively. These interactions
Caldecott, Keith W, El-Khamisy, Sherif F, Iles, Natasha, Rulten, Stuart   +3 more
core   +5 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. [PDF]

, 2013
Ataxia telangiectasia mutant (ATM) is an S/T-Q-directed kinase that is critical for the cellular response to double-stranded breaks (DSBs) in DNA. Following DNA damage, ATM is activated and recruited by the MRN protein complex [meiotic recombination 11 ...
Chen, C, Huang, B, Huang, NJ, Kornbluth, S, Zhang, L   +4 more
core   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Reprint of “The clinical impact of deficiency in DNA non-homologousend-joining” [PDF]

, 2014
DNA non-homologous end-joining (NHEJ) is the major DNA double strand break (DSB) repair pathway inmammalian cells. Defects in NHEJ proteins confer marked radiosensitivity in cell lines and mice models,since radiation potently induces DSBs. The process of
Ahnesorg, Alt, Ambrose, Andres, Andrew R. Gennery, Bacon, Bajin, Barnes, Bednarski, Bednarski, Blunt, Bosma, Bowen, Britton, Buck, Buck, Callebaut, Cantagrel, CavazzanaCalvo, Chase, Cottarel, Critchlow, Dai, de Villartay, de Villartay, Drouet, Dutrannoy, Dvorak, Ege, Egger, Enders, Evans, Faraci, Fattah, Felgentreff, Feng, Frank, Frank, Gao, Gatz, Girard, Goodarzi, Goodarzi, Gottlieb, Grawunder, Grawunder, Gruhn, Grunebaum, Hammel, Hartley, Hentges, Ijspeert, International Nijmegen Breakage Syndrome Study Group, Jacobs, Jeggo, Kegel, Krempler, Lahdesmaki, Lee, Li, Lisa Woodbine, Ma, Mahaney, Martin, Matsumoto, McKinnon, Meek, Merkle, Mitsuhashi, Moshous, Moshous, Nicolas, Nijnik, Nijnik, O’Driscoll, O’Driscoll, O’Driscoll, O’Marcaigh, Paillard, Pannicke, Pannicke, Peake, Penny A. Jeggo, Plowman, Pontious, Riballo, Riballo, Riballo, Riballo, Rohr, Rooney, Rucci, Ruis, Shibata, Sibanda, Sibanda, Taylor, Thornton, Toita, Tomkinson, Tsai, Turul, van der Burg, van der Burg, van Gent, Walker, Waltes, Wang, Wang, Wei, Woodbine, Woodbine, Woodbine, Wu, Yue, Zha, Zolner   +116 more
core   +1 more source

Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. [PDF]

, 2015
Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper,
Briggs, Steven P, Kim, Jinchul, Lee, Pei-Jen, Shen, Zhouxin, Su, Ning-Yuan, Todorova, Dilyana, Xiong, Jianhua, Xu, Yang   +7 more
core  

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava, Sudhakar Venkatesh, Michael S. Torbenson, Patrick S. Kamath, Moira Hilscher   +4 more
wiley   +1 more source

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer

Cell Reports, 2018
Summary: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality.
Rachel M. Guerra, Gregory H. Bird, Edward P. Harvey, Neekesh V. Dharia, Kyle J. Korshavn, Michelle S. Prew, Kimberly Stegmaier, Loren D. Walensky   +7 more
doaj   +1 more source

Transcription-dependent Activation of Ataxia Telangiectasia Mutated Prevents DNA-dependent Protein Kinase-mediated Cell Death in Response to Topoisomerase I Poison [PDF]

, 2010
Ryo Sakasai, Hirobumi Teraoka, Masatoshi Takagi, Randal S. Tibbetts   +3 more
openalex   +1 more source

Supplementary Figure 1 from DNA Protein Kinase–Dependent G₂ Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells [PDF]

, 2023
Sonnet J.H. Arlander, Bryan T. Greene, Cynthia L. Innes, Richard S. Paules   +3 more
openalex   +1 more source