Results 151 to 160 of about 33,965 (276)
A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers [PDF]
, 2010 Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
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Considering the role of Murine double minute 2 in the cardiovascular system [PDF]
, 2019 The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53 ...
Lam, Brian, Roudier, Emile
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Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention
Cancer Medicine, Volume 15, Issue 2, February 2026.Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa +4 more
wiley +1 more source
Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase [PDF]
, 2011 Edward A. Nam +2 more
openalex +1 more source
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source
LiCl causes an acute decrease in ataxia telangiectasia mutated (ATM) protein levels in L6 myotubes
The FASEB Journal, 2010 We have previously found that insulin‐like growth factor 1 (IGF‐1) causes an acute increase in levels of ATM in cultured myotubes and in mouse skeletal muscle and that serum starvation (SS) of myotubes causes concomitant increases in levels of the AMP‐activated protein kinase (AMPK) and ...
Rona Robinson‐Hill +2 more
openaire +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor.
Lei Lang +13 more
doaj +1 more source
Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source
Chinese Medical Journal. Background:. Long non-coding RNAs (lncRNAs) plays an important role in the progression of gastric cancer (GC). Their involvement ranges from genetic regulation to cancer progression.
Wenwei Liu +9 more
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Cancer Management and Research, 2022 Xiwen Wang, Jungang Zhao Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, People’s Republic of ChinaCorrespondence: Jungang ZhaoDepartment of Thoracic Surgery, Shengjing Hospital of China Medical
Wang X, Zhao J
doaj