Results 51 to 60 of about 33,965 (276)

Ataxia‐telangiectasia‐mutated protein expression with microsatellite instability in gastric cancer as prognostic marker [PDF]

International Journal of Cancer, 2013
The prognostic significance of ataxia‐telangiectasia‐mutated (ATM) expression in gastric cancer remains unclear. The functional loss of ATM gene exhibits a biologic correlation with microsatellite instability (MSI). In this study, we investigated the significance of ATM expression with MSI by evaluating gastric cancer patients who had underwent ...
Jin Won, Kim, Seock-Ah, Im, Min A, Kim, Hyun Jin, Cho, Dae Won, Lee, Kyung-Hun, Lee, Tae-Yong, Kim, Sae-Won, Han, Do-Youn, Oh, Hyuk-Joon, Lee, Tae-You, Kim, Han-Kwang, Yang, Woo Ho, Kim, Yung-Jue, Bang   +13 more
openaire   +2 more sources

Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis

Chinese Medical Journal, 2015
Background: Caffeine suppresses ataxia telangiectasia and Rad3 related and ataxia telangiectasia mutated (ATM) activities; ATM is the major kinase for DNA damage detection.
Zhe-Wei Zhang, Jing Xiao, Wei Luo, Bo-Han Wang, Ji-Min Chen   +4 more
doaj   +1 more source

Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. [PDF]

PLoS ONE, 2013
Although structurally and biochemically similar to the cellular prion (PrP(C)), doppel (Dpl) is unique in its biological functions. There are no reports about any neurodegenerative diseases induced by Dpl.
Kefeng Qin, Tianbing Ding, Yi Xiao, Wenyu Ma, Zhen Wang, Jimin Gao, Lili Zhao   +6 more
doaj   +1 more source

An essential function for the ATR-Activation-Domain (AAD) of TopBP1 in mouse development and cellular senescence [PDF]

, 2013
ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins – Dpb11TopBP1, Ddc1Rad9 and Dna2 - all interact with and activate Mec1ATR.
A Aguilera, A Balestrini, A Ciccia, A de Klein, A Kumagai, A Kumagai, A Mavrou, Anja Krueger, Antony M. Carr, C Cotta-Ramusino, Christopher Bruhn, Cong Liu, D Boos, D Branzei, D Cortez, DA Mordes, DA Mordes, EA Nam, EJ Brown, EJ Brown, FD Sweeney, H Wang, HL Ball, HY Yoo, J Lee, JE Kim, K Furuya, K Liu, K Liu, K Liu, K Liu, K Yamane, KA Cimprich, L Zou, L Zou, LA Lindsey-Boltz, LI Toledo, M Qu, Marshall S. Horwitz, O Limbo, P Bork, P Zegerman, PJ Woolf, R Gruber, RJ Edwards, S Biton, S Delacroix, S Kumar, S Liu, S Mochida, SJ Lin, SP Jackson, T Usui, Tang-Liang Li, V Garcia, VM Navadgi-Patil, VM Navadgi-Patil, WooKee Min, X Xu, X Yu, Y Jeon, Y Jeon, Y Lee, Z You, Z Zhou, Zhao-Qi Wang, Zhong-Wei Zhou, ZQ Wang   +67 more
core   +3 more sources

Cellular Radiosensitivity: How much better do we understand it? [PDF]

, 2009
Purpose: Ionizing radiation exposure gives rise to a variety of lesions in DNA that result in genetic instability and potentially tumorigenesis or cell death.
Agrawal A, Ahel I, Ahnesorg P, Ali A, Anderson RM, Awa AA, Azzam E.I., Bailey SM, Bakkenist CJ, Beamish H, Bedford JS, Bedford JS, Bender MA, Berkovich E, Biedermann KA, Blunt T, Booth C, Bosma GC, Breslin C, Brown GL, Brown JM, Buck D, Carney JP, Cerosaletti K, Cerosaletti K, Chan DW, Chan DW, Chapman JD, Chen P.C., Clements PM, Cornforth MN, Cornforth MN, Cornforth MN, Curtis SB, Davis ME, de Jager M, Deans B, Dianor II, Ding Q, Dizdaroglu M, Doil C, El-Khamisy SF, El-Khamisy SF, Emmerson PT, Falck J, Falck J, Foray N, Game JC, Gao Y, Gatti RA, Georgakilas AG, Germain M, Godthelp BC, Goffman TE, Goldman M, Goldstein L, Goodarzi AA, Goodarzi AA, Goodhead DT, Grawunder U, Gueven N, Gueven N, Gueven N, Hirano M, Ho KS, Ho KY, Holliday R, Hopfner KP, Houldsworth J, Huen MS, Iliakis G, Iliakis G, Iliakis G, Jackson SP, Jazayeri A, Jeggo PA, Jeggo PA, Jeggo PA, Jeggo PA, Joiner MC, Joiner MC, Kankura T, Kastan MB, Kato TA, Kemp LM, Kemp LM, Khanna KK, Kitagawa R, Kolas NK, Kozlov SV, Krueger SA, Kurz EU, Lavin MF, Lavin MF, Lehmann AR, Li Z, Lindahl T, Lisker R, Little JB, Liu N, Liu Y, Lobrich M, Lockart RZ, Loken MK, Macklis RM, Mailand N, Marples B, Marples B, Martin F. Lavin, Maser RS, Miller RW, Mirzoeva OK, Morgan WF, Morgan WF, Moshous D, Mothersill C, Moynahan ME, Muhlmann-Diaz MC, Muller B, Nakamura J, Neel JV, Nelms BE, Nicolas N, Nikjoo H, O'Driscoll M, O'Driscoll M, Olive PL, Olive PL, Otake M, Ouyang H, Painter RB, Pandita TK, Parsons PA, Paull TT, Paull TT, Paull TT, Penny Jeggo, Peters LJ, Potten CS, Pourquier P, Pourquier P, Purdy JA, Radford IR, Radford JR, Ratnayake RK, Resnick MA, Riballo E, Robins HI, Rothkamm K, Rothkamm K, Rothkamm K, Royal HD, Samson L, Savitsky K, Sax K, Sedgwick RP, Shinohara A, Shreeram S, Singh NP, Spivak G, Stamato TD, Stamato TD, Stewart GS, Stewart GS, Stewart GS, Strzelczyk JJ, Sun Y, Sun Y., Sutherland JC, Taccioli GE, Takashima H, Tapio S, Taylor AM, Taylor AMR, Teoule R, Terasima T, Thacker J, Thacker J, Thacker J, Thierry-Chef I, Thompson LH, Thompson LH, Uziel T, van den Bosch M, van der Schans GP, Varon R, von Sonntag C, Walker JR, Wall BF, Wallach DF, Waltes R, Ward IM, Ward JF, Ward JF, Weemaes CMR, Whitmore GF, Willetts NS, Williams RS, Wolff S, Wolff S, Wolff S, Wolff S, Woo SY, Wood RD, Wykes SM, Wyman C, Yoshimaru H, Yoshimoto Y, You Z, Zdzienicka MZ, Zdzienicka MZ, Zdzienicka MZ, Zhao W, Zhou T, Ziv Y   +214 more
core   +1 more source

Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

Cell Reports, 2012
Ataxia telangiectasia mutated (ATM) protein kinase activation by DNA double-strand breaks (DSBs) requires the Mre11-Rad50-NBS1 (MRN) complex, whereas ATM interactor (ATMIN) protein is required for ATM signaling induced by changes in chromatin structure ...
Tianyi Zhang, Kay Penicud, Christopher Bruhn, Joanna I. Loizou, Nnennaya Kanu, Zhao-Qi Wang, Axel Behrens   +6 more
doaj   +1 more source

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM [PDF]

Journal of Biological Chemistry, 2002
Chromosome aberrations, genomic instability, and cancer predisposition are hallmarks of a number of syndromes in which the defective genes recognize and/or repair DNA damage or are involved in some aspect of DNA processing. We report here direct interaction between BLM, mutated in Bloom's Syndrome (BS), and ATM, mutated is ataxia-telangiectasia, and we
Heather Beamish, Padmini S. Kedar, Hideo Kaneko, Philip Chen, Toshiyuki Fukao, Cheng Peng, Sergei Beresten, Nuri Gueven, David M. Purdie, Susan P. Lees‐Miller, Nathan A. Ellis, Naomi Kondo, Martin F. Lavin   +12 more
openalex   +4 more sources

Mutations in pathways depending on BRCA1 and BRCA2 may increase cancer risks from an environmental carcinogen [PDF]

, 2011
Recently, the President’s Cancer Panel [2008-2009] protested that preventive action is not taken when uncertainty exists about potential harm from a chemical, because the US regulatory approach demands that a hazard be incontrovertibly ...
Bernard Friedenson
core   +2 more sources

Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint [PDF]

Journal of Biological Chemistry, 2012
Dbf4/Cdc7 (Dbf4-dependent kinase (DDK)) is activated at the onset of S-phase, and its kinase activity is required for DNA replication initiation from each origin. We showed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replication initiation and to protect replication forks.
Alan Yueh-Luen, Lee, Takuya, Chiba, Lan N, Truong, An Ning, Cheng, Johnny, Do, Michael Jeffrey, Cho, Longchuan, Chen, Xiaohua, Wu   +7 more
openaire   +2 more sources

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Scientific Reports, 2022
The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes
Sachita Ganesa, Amrita Sule, Ranjini K. Sundaram, Ranjit S. Bindra   +3 more
doaj   +1 more source