Results 121 to 130 of about 31,821 (205)

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide [PDF]

, 2016
Autophagy plays important roles in many biological processes, but our understanding of the mechanisms regulating stem cells by autophagy is limited.
Apel, Bjørkøy, Boya, Chenran Wang, Conway, Dröge, Eileen White, Fujita, Gan, Gan, Gizem Karsli-Uzunbas, Guo, Hara, Hara, He, Herbert W. Virgin, Huang, Huang, Hwang, Jun-Lin Guan, Jung, Karsli-Uzunbas, Kenific, Kirkin, Kishi-Itakura, Komatsu, Komatsu, Komatsu, Komatsu, Komatsu, Kuma, Lee, Li, Liang, Liang, Lin, Liu, Lombard, Lv, Mathew, Matés, Melov, Misawa, Mizushima, Mizushima, Murphy, Naka, Newman, Nishida, Noboru Mizushima, Noda, Okada, Pankiv, Qu, Rhee, Rubinsztein, Saitoh, Song Chen, Sou, Syn Yeo, Takamura, Tsang, Vázquez, Wang, Wei, Wen, White, Yang, Yazdankhah, Yue, Zelko, Zeng, Zhu   +72 more
core   +2 more sources

ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1

Cell Death and Disease
Although autophagy-related gene 7 (ATG7) acts as an E1-like activating enzyme and is essential for autophagy, it frequently performs broader roles involved in the modulation of diverse signaling pathways that affect cell proliferation, survival ...
Kangdi Li, Ting Liu, Zhihong Luo, You Yu, Yi Liu, Zhaoqing Zhang, Wenhua Li   +6 more
doaj   +1 more source

Endothelial autophagy-related gene 7 contributes to high fat diet-induced obesity

Molecular Metabolism
Objective: Obesity-associated metabolic dysfunction is a major public health concern worldwide. Endothelial dysfunction is a hallmark of metabolic dysfunction, and endothelial cells affect metabolic functions.
Guang Ren, Sushant Bhatnagar, Martin E. Young, Timmy Lee, Jeong-a Kim   +4 more
doaj   +1 more source

Characterization of ATG7 protein coding isoforms

, 2023
ATG7, an essential protein for cellular homeostasis, plays a pivotal role in regulating autophagy. The autophagy process ensures the degradation and recycling of cellular components for proper cell function. ATG7 facilitates the lipidation of ATG8 proteins, a vital step in autophagosome formation. Notably, ATG7 is expressed as two mRNA splice variants,
openaire   +1 more source

Identification of ATG7 as a protein ATG8ylation substrate

Cell Reports
Summary: Protein ATG8ylation is a post-translational modification where ubiquitin-like protein LC3/ATG8 forms covalent conjugation with cellular proteins, a process reversed by ATG4.
Huazhong Xie, Jiahui Long, Yijun Huang, Yao Wang, Peiqing Liu, Min Li   +5 more
doaj   +1 more source

Serum level of autophagy-related protein 7 (Atg7) in children with complicated pneumonia

Egyptian Pediatric Association Gazette
Background Community-acquired pneumonia (CAP) is one of the primary causes of morbidity and mortality in children. Autophagy-related protein 7 (Atg7) is a key autophagy effector enzyme that regulates immunity and cell death in combination with other Atg ...
Tharwat Deraz, Yara Taher, Sara Taha, Sally Ishak   +3 more
doaj   +1 more source

Reduction of microRNA-221 in BVDV infection enhances viral replication by targeting the ATG7-mediated autophagy pathway

Irish Veterinary Journal
Background Bovine viral diarrhoea (BVD), a condition triggered by bovine viral diarrhoea virus (BVDV), is recognized globally as a prevalent pathogen among ruminants and markedly affects the economics of animal husbandry.
Zihan Chen, Jingyu Wang, Baochun Lu, Wenxin Meng, Yufan Zhu, Qifeng Jiang, Duo Gao, Zihang Ma, Huijuan Zeng, Jinping Chen, Shizhe Liu, Zhen Wang, Kun Jia   +12 more
doaj   +1 more source

ATG7 autophagy related 7 homolog (ATG7) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

miR-223-3p靶向自噬相关蛋白7调控鼻咽癌细胞自噬

Zhongguo shiyan zhenduanxue, 2022
目的 探讨miR-223-3p是否靶向自噬相关蛋白7(Autophagy-related 7,ATG7)以调节鼻咽癌细胞的自噬。方法 使用TargetScan分析miR-223-3p与ATG7的相关性。荧光素酶测定法用于检测miR-223-3p是否靶向ATG7。通过Western blot检测miR-223-3p在鼻咽癌细胞CNE2中的过度表达或敲低,检测鼻咽癌细胞CNE2中ATG7的表达以及自噬标记蛋白P62和LC3-Ⅱ的表达。结果 miR-223-3p靶向ATG7的3’UTR位于2791 ...
doaj  

ATG7 autophagy-related 7 homolog (ATG7) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source