Results 101 to 110 of about 31,821 (205)
Reproductive Biology and Endocrinology, 2022 Background Nonobstructive azoospermia (NOA) is one of the most difficult forms of male infertility to treat, and its pathogenesis is still unclear. miRNAs can regulate autophagy by affecting their target gene expression. Our previous study found that miR-
Yuan Wang +10 more
doaj +1 more source
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance [PDF]
, 2014 Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity.
Chan, Chang S. +10 more
core +2 more sources
A Decline in Follicle Cell Function Is a Major Driver of Drosophila Ovarian Aging
Aging Cell, Volume 25, Issue 5, May 2026.Aging drives a progressive accumulation of defects in somatic follicle cells of the Drosophila ovary. These defects are accompanied by reduced tissue and genome integrity, altered transcriptional profiles, and disrupted germ‐soma coordination. Targeted overexpression of Atg8a in a subset of follicle cells mitigates these defects and preserves ...
Emily A. Wolfgram, Todd G. Nystul
wiley +1 more source
Chronic smoke exposure is associated with autophagy in murine Peyer's patches [PDF]
, 2011 INTRODUCTION: Cigarette smoke causes oxidative stress, leading to smoke-induced autophagy in several organs. Autophagy is a homeostatic process regulating the turnover of proteins and cytoplasmatic organelles.
Allais, Liesbeth +5 more
core +1 more source
Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacological modulation [PDF]
, 2015 Acute myeloid leukemia (AML) is characterized by the accumulation of immature blood cell precursors in the bone marrow. Pharmacologically overcoming the differentiation block in this condition is an attractive therapeutic avenue, which has achieved ...
Ablain +60 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1901-1919, May 2026.Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao +12 more
wiley +1 more source
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling
Cell Communication and Signaling, 2019 Background Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death.
Wei Zheng +5 more
doaj +1 more source
The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]
, 2017 We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan +10 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3426-3440, May 2026.ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk +15 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2017 Human bladder cancer (BC) is the fourth most common cancer in the United States. Investigation of the strategies aiming to elucidate the tumor growth and metastatic pathways in BC is critical for the management of this disease.
Junlan Zhu +11 more
doaj +1 more source