Results 81 to 90 of about 25,612 (182)

p62 aggregates sequester Atg7 in a LC3-dependent manner.

, 2013
GFP-Atg7 (Aa), GFP-Atg7/Flag-LC3 (Ab), or GFP-Atg7C572A/Flag-LC3 (Ac) vectors were co-transfected with mRFP-p62 into MEFwt cells for 48 h. GFP-Atg7 punctae were shown; mRFP-p62 and Flag-LC3 with GFP-Atg7 vectors (B) or with GFP-Atg7C572A(C) were co ...
Zhixia Chen (454027), Michael T. Stang (454028), Wei Wang (17594), Wentao Gao (109734)   +3 more
core   +1 more source

Skilgreining á hryggdýrasértæku svæði ATG7

The autophagy pathway, mediated by autophagy related genes (ATGs), is activated by cellular stress and is important for cellular homeostasis. Atg7 is a key autophagy gene, and mammalian cells lacking Atg7 are unable to facilitate lipidation of LC3.
Katrín Anna Lárusdóttir 2002-
core   +1 more source

Glucocorticoids Impair the Airway Epithelial Barrier via Autophagy‐Associated Apoptosis in Asthma: A Preliminary Study Both In Vitro and In Vivo

Pediatric Discovery, EarlyView.
Mechanism underlying the negative effects of glucocorticoids on the airway epithelial barrier. Glucocorticoids upregulate autophagy factors and downregulate anti‐autophagy factors. Enhanced autophagy promotes excessive apoptosis and epithelial detachment, impairing airway barrier function.
Hao You, Wenjing Zou, Tangqiaochu Gan, Yu Zhao, Jie Hu, Wen Tan, Ting Wang, Luo Ren, Zhengxiu Luo, Zhou Fu, Chao Niu   +10 more
wiley   +1 more source

Atg7 regulates morphological plasticity of mature dopaminergic axon terminals.

, 2013
(A) Scheme of AAV2-Cre/GFP viral transduction of adult Atg7flox/flox substantia nigra. Eight-week-old Atg7flox/+ and Atg7flox/flox mice were stereotactically injected with AAV2-Cre/GFP viral solution, and sacrificed 4- or 8-weeks later.
Joanne Rispoli (466262), M. Flint Beal (70809), Asa Abeliovich (70811), Eric Klann (241569), David MacLeod (466263), Lichuan Yang (70810), Keiichi Inoue (466261)   +6 more
core   +1 more source

Control of ATG7 by NOD2.

, 2023
We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of autophagy-related 7 (ATG7) by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein ...
Shahan Mamoor
core   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

The role of ATG7 in liver cancer

, 2017
Sjálfsát er nauðsynlegt ferli sem gegnir mikilvægu hlutverki í að viðhalda samvægi í heilkjarna frumum. Sjálfsátskornið er einstakt frumulíffæri og myndun þess er lykilskref í sjálfsáti.
Ásta Kristensa Steinsen 1994-
core   +1 more source

Heterozygous Atg7 knockout in striatal DRD2 neurons.

, 2015
(A) Representative images of ATG7 immunoreactive DRD2 neurons. The pictures were captured under fluorescent microscope after immunostaining. Arrows indicate blue nuclei surrounded by immunoreactivities of ATG7 and DRD2. (B) total number of DAPI(+) nuclei.
Ya-Ching Hsieh (599086), Chin Hsu (304861), Pei-Chi Chiang (766040), Kazunari K. Yokoyama (278798), Tzu-Yin Chen (766038), Hsiu-Wen Hsiao (766039), Steven Lo (599081), Li-Fang Wang (188178)   +7 more
core   +1 more source

ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1

Cell Death and Disease
Although autophagy-related gene 7 (ATG7) acts as an E1-like activating enzyme and is essential for autophagy, it frequently performs broader roles involved in the modulation of diverse signaling pathways that affect cell proliferation, survival ...
Kangdi Li, Ting Liu, Zhihong Luo, You Yu, Yi Liu, Zhaoqing Zhang, Wenhua Li   +6 more
doaj   +1 more source

Liquiritigenin Ameliorates High‐Fat Diet‐Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2‐ATGL Regulation

Phytotherapy Research, EarlyView.
Liquiritigenin promotes expression of CGI‐58 and enhances lipolysis by down‐regulating expression of PLIN2, thereby facilitating the catabolism of larger‐sized lipid droplets and producing smaller‐sized lipid droplets, resulting in enhanced activity of lipophagy and ameliorated hepatic steatosis. ABSTRACT Metabolic‐associated fatty liver disease (MAFLD)
Zhuoya Xu, Jingmiao Chen, Hong Qin, Yansong Fu, Cunqi Lv, Zhipeng Wang, Xi Liu, Wenya Zheng   +7 more
wiley   +1 more source