Results 71 to 80 of about 25,612 (182)

Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss

Frontiers in Cellular Neuroscience, 2019
Radiotherapy is an effective tool for treating brain tumors, but irradiation-induced toxicity to the normal brain tissue remains a major problem. Here, we investigated if selective neural autophagy related gene 7 (Atg7) deletion has a persistent effect ...
Yafeng Wang, Yafeng Wang, Yafeng Wang, Kai Zhou, Kai Zhou, Tao Li, Tao Li, Tao Li, Yiran Xu, Yiran Xu, Cuicui Xie, Cuicui Xie, Yanyan Sun, Yanyan Sun, Juan Rodriguez, Shan Zhang, Shan Zhang, Juan Song, Juan Song, Xiaoyang Wang, Xiaoyang Wang, Klas Blomgren, Klas Blomgren, Klas Blomgren, Changlian Zhu, Changlian Zhu   +25 more
doaj   +1 more source

Decoding ferroptosis via integrated multi‐omics analyses in rice blast

iMeta, EarlyView.
The rice‐Magnaporthe oryzae pathosystem is presented as a host‐pathogen ferroptosis model. Multi‐omics insights connect ferroptosis to several cellular processes, such as iron homeostasis, reactive oxygen species (ROS)/redox imbalance, and polyunsaturated fatty acid‐containing phospholipid (PUFA‐PL) peroxidation, under multiple regulators in rice and M.
Zhibin Liang, Qing Shen, Nam Khoa Nguyen, Ruhui Long, Yuming Ma, Qiao Liu, Naweed I. Naqvi, Nam‐Soo Jwa, Yi‐Zhen Deng   +8 more
wiley   +1 more source

Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer

Journal of Experimental & Clinical Cancer Research
Background The efficacy of anti-PD-1 therapy is primarily hindered by the limited T-cell immune response rate and immune evasion capacity of tumor cells.
Wenxin Zhang, Lu Chen, Jiafeng Liu, Bicui Chen, Huanying Shi, Haifei Chen, Huijie Qi, Zimei Wu, Xiang Mao, Xinhai Wang, Yuxin Huang, Jiyifan Li, Zheng Yu, Mingkang Zhong, Tianxiao Wang, Qunyi Li   +15 more
doaj   +1 more source

ATG7 Overexpression Is Crucial for Tumorigenic Growth of Bladder Cancer In Vitro and In Vivo by Targeting the ETS2/miRNA196b/FOXO1/p27 Axis

Molecular Therapy: Nucleic Acids, 2017
Human bladder cancer (BC) is the fourth most common cancer in the United States. Investigation of the strategies aiming to elucidate the tumor growth and metastatic pathways in BC is critical for the management of this disease.
Junlan Zhu, Yang Li, Zhongxian Tian, Xiaohui Hua, Jiayan Gu, Jingxia Li, Claire Liu, Honglei Jin, Yulei Wang, Guosong Jiang, Haishan Huang, Chuanshu Huang   +11 more
doaj   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

ATG7-expression and chemerin secretion are co-regulated in adipocytes

, 2018
Background: In obese individuals, adipocyte endocrine function is affected by altered autophagy. In a recent genome-wide association study (GWAS) genetic variants in autophagy-related gene 7 (ATG7) correlated with serum chemerin (RARRES2 ...
Piaggi, P, J Weiner, A Tönjes, Stumvoll, M, L Baier, S Heinitz, A Rudich, M Stumvoll, Blüher, M, H Heyne, Baier, L, P Kovacs, Tönjes, A, Heyne, H, Kovacs, P, J Krüger, Gebhardt, C, Weiner, J, Heinitz, S, Krüger, J, P Piaggi, M Blüher, C Gebhardt, Heiker, J, Rudich, A, J Heiker   +25 more
core   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Regulation of ATG7 modulates drug sensitivity in SCC61.

, 2014
A) Depletion of ATG7 protein expression in SCC61 cells reduced LC3-II. SCC61 cells were transfected with control siRNA or ATG7 siRNA and analyzed by western blotting. LC3-II protein was quantified and the results shown graphically.
Omar Ahmed (530933), Wen-Liang Kuo (530932), Marina N. Sharifi (311843), Ezra E. W. Cohen (186351), Mark W. Lingen (250859), Kay F. Macleod (530935), Madhavi Nagilla (530934), Jing Liu (38537)   +7 more
core   +1 more source

Створення потенційних Ilp-маркерів для генів Atg2, Atg7, Atg8 у Hordeum vulgare і H. marinum

Фактори експериментальної еволюції організмів
Мета. Створення потенційних маркерів поліморфізму довжини інтронів для генів ATG2, ATG7 і ATG8. Методи. Методи класичної біоінформатики для пошуку локусів, що кодують білки ATG2, ATG7, ATG8 у геномі Hordeum marinum на основі гомології з генами ...
D. O. Novozhylov, S. O. Hordynskyi, A. M. Rabokon, A. Ye. Demkovych, S. M. Pryvalikhin, R. Y. Blume, А. Yu. Buziashvili, A. I. Yemets, Ya. V. Pirko   +8 more
doaj   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source