Results 51 to 60 of about 25,612 (182)

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline

Molecular Metabolism
Background: Myoprotein degradation accelerates in obese individuals, resulting in a decline in muscular mass. Atg7 plays a crucial role in regulating protein stability and function through both autophagy-dependent and independent pathways.
Yang Yu, Jing Yang, Lixia Zheng, Han Su, Sunrun Cao, Xuehan Jiang, Xiyan Liu, Weiwei Liu, Zhuo Wang, Fang Meng, Hongde Xu, Deliang Wen, Chen Sun, Xiaoyu Song, Antonio Vidal-Puig, Liu Cao   +15 more
doaj   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Intracellular alpha-fetoprotein interferes with all-trans retinoic acid induced ATG7 expression and autophagy in hepatocellular carcinoma cells

Scientific Reports, 2021
Retinoic acid and retinoid acid receptor (RA-RAR) signaling exhibits suppressive functions in the progression of hepatocellular carcinoma (HCC) through multiple mechanisms.
Shanshan Wang, Rilu Feng, Ying Shi, Dexi Chen, Honglei Weng, Huiguo Ding, Chenguang Zhang   +6 more
doaj   +1 more source

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression

Cell Death and Disease, 2022
Dysregulation of autophagy and circular RNAs (circRNAs) are involved in the pancreatic cancer (PC) progression. However, the regulatory network between circRNAs, autophagy, and PC progression remains unknown.
Zhiwei He, Kun Cai, Zhirui Zeng, Shan Lei, Wenpeng Cao, Xiaowu Li   +5 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Greining á spendýrasértæku hlutverki ATG7

, 2019
Introduction: Autophagy is a cell degradation pathway and is upregulated during starvation. It is the cell’s way to clean up faulty cellular components, survive different stressors, such as starvation, as well as being a source of energy for the cell ...
Júlía Björg Kristbjörnsdóttir 1992-
core   +1 more source

Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. [PDF]

PLoS Genetics, 2013
Macroautophagy is a conserved mechanism for the bulk degradation of proteins and organelles. Pathological studies have implicated defective macroautophagy in neurodegeneration, but physiological functions of macroautophagy in adult neurons remain unclear.
Keiichi Inoue, Joanne Rispoli, Lichuan Yang, David Macleod, M Flint Beal, Eric Klann, Asa Abeliovich   +6 more
doaj   +1 more source

Characterisation of a Novel Isoform of ATG7

, 2019
Sjálfsát er niðurbrotsferli sem tekur þátt í að viðhalda jafnvægi innan frumunnar. Hlutverk þess er að hreinsa umfrymið, til dæmis fjarlægja próteinkekki, lípíð eða skemmd frumulíffæri.
Hildigunnur Hermannsdóttir 1996-
core   +1 more source

Electrophysiological analysis of atg7^flox control and atg7-SCKO mice.

, 2015
Four animals at age P60~70 in each group were tested.NS; not significant, Student’s two-tailed testElectrophysiological analysis of atg7flox control and atg7-SCKO mice.
Joo Youn Park (201915), So Young Jang (683072), Hye Jeong Lee (683076), So Young Park (435900), Jong Kuk Kim (683075), Hwan Tae Park (683077), Yoon Kyung Shin (683073), Seo-Hee Rha (683074)   +7 more
core   +1 more source